盐酸托莫西汀治疗注意缺陷多动障碍患儿的体重降低情况及危险因素和对策分析  

Analysis of weight loss,risk factors and countermeasures of Atomoxetine Hydrochloride in children with attention deficit hyperactivity disorder

作　　者：贾芝妮 汪金梅 欧阳萍 JIA Zhini;WANG Jinmei;OUYANG Ping(Department of Pediatrics,Pingxiang Maternity and Child Care,Jiangxi Province,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市妇幼保健院儿科,江西萍乡337000

出　　处：《中国当代医药》2023年第25期117-120,共4页China Modern Medicine

基　　金：江西省萍乡市科技计划项目(2021PY187)。

摘　　要：目的探究盐酸托莫西汀治疗注意缺陷多动障碍(ADHD)患儿的体重降低发生情况及其危险因素,总结干预对策。方法回顾性分析2019年1月至2021年12月萍乡市妇幼保健院收治的80例注意力缺陷多动障碍患儿,均采用盐酸托莫西汀治疗,根据患儿治疗前、治疗1个月后的体重变化情况进行分组,将无体重下降的43例患儿(体重较基线下降范围1~2 kg)作为无体重下降组,将体重明显下降(体重较基线下降范围3~7 kg)的37例患儿作为体重下降组,采用logistic回归分析筛选盐酸托莫西汀治疗ADHD患儿致体重降低的独立危险因素。结果患儿体重下降37例,体重下降率为46.25%;两组患儿的性别、年龄、身高、病程比较,差异无统计学意义(P>0.05);体重下降组患儿的体重重于无体重下降组,差异有统计学意义(P<0.05);体重下降组患儿用药次数1次/d、无营养支持例数多于无体重下降组,差异有统计学意义(P<0.05);体重下降组患儿饮食情况、营养状况差于无体重下降组,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示:体重(β=0.759、OR=2.136、95%CI:1.319~3.460)、给药次数(β=0.725、OR=2.065、95%CI:1.042~4.092)、饮食情况(β=0.475、OR=1.608、95%CI:1.051~2.460)、营养状况(β=0.652、OR=1.919、95%CI:1.142~3.227)均为口服盐酸托莫西汀治疗ADHD患儿体重下降的独立危险因素(P<0.05)。结论对于ADHD患儿,口服盐酸托莫西汀治疗时体重下降发生率较高,应密切观察患儿给药次数、营养状况等,给予积极的干预,以降低患儿体重下降风险。Objective To investigate the incidence and risk factors of weight loss in children with attention deficit hyperactivity disorder(ADHD)treated with Atomoxetine Hydrochloride,and to summarize the intervention strategies.Methods A retrospective analysis was performed on 80 children with attention deficit hyperactivity disorder admitted to Pingxiang Maternity and Child Care from January 2019 to December 2021.All children were treated with Atomoxetine Hydrochloride.The children were grouped according to the weight change before treatment and 1 month after treatment.Forty-three children with no weight loss(weight loss of 1-2 kg from baseline)were selected as the non-weight loss group,and 37 children with significant weight loss(weight loss of 3-7 kg from baseline)were selected as the weight loss group.Logistic regression analysis was used to screen the independent risk factors for weight loss in ADHD children treated with Atomoxetine Hydrochloride.Results Thirty-seven cases had weight loss,and the weight loss rate was 46.25%.There were no significant differences in gender,age,height,and course of disease between the two groups(P>0.05).The weight loss group was heavier than the non-weight loss group,and the difference was statistically significant(P<0.05).The frequency of medication once a day and the number of children without nutritional support in the weight loss group were higher than those in the non-weight loss group,and the differences were statistically significant(P<0.05).The diet and nutritional status of children in the weight loss group were worse than those in the non-weight loss group,and the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that:body weight(β=0.759,OR=2.136,95%CI:1.319-3.460),times of administration(β=0.725,OR=2.065,95%CI:1.042-4.092),diet(β=0.475,OR=1.608,95%CI:1.051-2.460)and nutritional status(β=0.652,OR=1.919,95%CI:1.142-3.227)were independent risk factors for weight loss in ADHD children treated with oral Atomoxetine Hydrochloride

关 键 词：盐酸托莫西汀 注意缺陷多动障碍 体重降低 影响因素 

分 类 号：R729[医药卫生—儿科]