橡皮生肌膏联合银离子敷料对Ⅳ期骶尾部褥疮创面愈合和血清炎性细胞因子的影响  

Effect of Xiangpi Shengji Paste(橡皮生肌膏)Combined with Silver Ions Dressingon Serum Inflammatory Cytokines and Clinical Efficacy in Patients with Stage IVCaudal Bedsores

作　　者：胡浩[1] 曹开学 黄攀[1] 黄传文 万玲玲 易利艳 浦飞飞[2] HU Hao;CAO Kaixue;HUANG Pan;HUANG Chuanwen;WAN lingling;YI Yanli;PU Feifei(Union Jiangnan Hospital,Huazhong University of Science and Technology,Wuhan 430200,Hubei,China;Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei,China)

机构地区：[1]华中科技大学协和江南医院,湖北武汉430200 [2]华中科技大学同济医学院附属协和医院,湖北武汉430022

出　　处：《辽宁中医杂志》2023年第7期116-119,I0002,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81904231);中国博士后科学基金项目(2020M672369);湖北省博士后创新实践岗位项目(34)。

摘　　要：目的探讨橡皮生肌膏联合银离子敷料对Ⅳ期骶尾部褥疮患者创面愈合和血清炎性细胞因子的影响。方法选取2018年6月—2020年6月来院就诊且接受治疗的Ⅳ期骶尾部褥疮患者90例,根据随机数表法将患者分试验组(橡皮生肌膏联合银离子敷料)和对照组(银离子敷料),每组各45例。所有患者在常规清创后,对照组外用银离子敷料,试验组外用橡皮生肌膏联合银离子敷料。对比分析两组患者的血清炎性细胞因子变化情况、不同时间点创面炎性反应情况和创面愈合情况。结果两组患者处理后血清炎性细胞因子水平均逐渐降低。治疗后1周和治疗后2周,试验组患者血清炎性细胞因子水平显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者创面中重度炎症发生率均逐渐降低。治疗1周后、治疗2周后和治疗4周后,试验组患者的中重度炎症发生率均明显低于对照组,差异有统计学意义(P<0.05)。治疗8周后,试验组总有效率为93.33%(42/45),明显高于对照组总有效率77.78%(35/45),差异有统计学意义(P<0.05)。结论联合使用橡皮生肌膏和银离子敷料可有效降低Ⅳ期骶尾部褥疮中重度炎症的发生,降低炎性细胞因子水平,提高临床治疗有效率。Objective To investigate the effects of Xiangpi Shengji Paste(橡皮生肌膏)combined with silver ions dressingon wound healing and serum inflammatory cytokines in patients with stageⅣcaudal bedsores.Methods Ninety patients with stageⅣcaudal bedsores who were treated in the hospital from June 2018 to June 2020 were selected.According to random number table method,the patients were divided into experimental group(Xiangpi Shengji Paste combined with silver ions dressing)and control group(silver ions dressing),with 45 patients in each group.All patients were treated after routine debridement,silver ions dressingwas externally applied in the control group,and Xiangpi Shengji Paste combined with silver ions dressingwere externally applied in the experimental group.The changes of serum inflammatory cytokines,wound inflammatory response and wound healing at different time points were compared between the two groups.Results After treatment,the serum inflammatory cytokines levels in both groups decreased gradually.After oneand two weeks after treatment,the levels of serum inflammatory cytokines in the experimental group were significantly lower than those in the control group(P<0.05).After treatment,the incidence of moderate to severe wound inflammation in both groups gradually decreased.After one,twoand four weeks of treatment,the incidence of moderate and severe inflammation in the observation group was significantly lower than that in the control group,with statistical difference(P<0.05).After eight weeks of treatment,the total effective rate of the experimental group was 93.33%(42/45),significantly higher than that[77.78%(35/45)]of the control group,showing a statistical difference(P<0.05).Conclusion Combined use of Xiangpi Shengji Paste andsilver ions dressingcan effectively reduce the occurrence of moderate and severe inflammation in stageⅣcaudal bedsores,reduce the levels of inflammatory cytokinesand improve the clinical treatment efficiency.

关 键 词：橡皮生肌膏 银离子敷料 骶尾部褥疮 炎性细胞因子 

分 类 号：R632.1[医药卫生—外科学]