548例慢性咳嗽风咳证用药规律数据挖掘研究  

Data Mining Research on Medication Rules in 548 Cases of Chronic Cough with Wind Cough Syndrome

作　　者：罗敬月 史利卿[3] 季坤[3] 马建岭[3] 宋欢 李扭扭[3] 王丽云[3] 董尚娟 杨凯 王颖 LUO Jingyue;SHI Liqing;JI Kun;MA Jianling;SONG Huan;LI Niuniu;WANG Liyun;DONG Shangjuan;YANG Kai;WANG Ying(Beijing Chest Hospital,Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China;Beijing University of Chinese Medicine,Beijing 100029,China;Respiratory department of Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China;Qingdao Hospital of Traditional Chinese Medicine,Qingdao 266033,Shandong,China;Beijing Daxing District Hospital of Integrated Chinese and Western Medicine,Beijing 100076,China;Zhejiang Hospital of Traditional Chinese Medicine,Hangzhou 310006,Zhejiang,China)

机构地区：[1]首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所,北京101149 [2]北京中医药大学,北京100029 [3]北京中医药大学东方医院,北京100078 [4]青岛市中医医院,山东青岛266033 [5]北京市大兴区中西医结合医院,北京100076 [6]浙江省中医院,浙江杭州310006

出　　处：《辽宁中医杂志》2023年第6期28-32,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：北京市自然科学基金项目(7184224,7192115);国家自然科学基金项目(81373588)。

摘　　要：目的探讨慢性咳嗽风咳证用药规律,以期为临床辨治提供参考。方法基于北京中医药大学东方医院咳嗽专病门诊病案资料,建立数据库,对方药进行频数分析,运用数据挖掘软件进行关联规则和聚类分析。结果共纳入处方548首,涉及中药139味,常用药类为降气止咳药、清热药、宣肺解表药、化湿药、祛风药等,味多辛、苦,属温性,多入肺、胃、脾经。常用药对有麻黄-旋覆花、薏苡仁-白豆蔻、麻黄-前胡、芦根-白茅根、苏子-苏梗、桂枝-茯苓等。核心处方药物组成为麻黄、黄芩、前胡、厚朴、紫菀、款冬花、青风藤。结论结果表明慢性咳嗽风咳证具有多重病机,治疗以祛风宣肺为基本治法,需兼顾湿热、寒饮、肺脾亏虚等兼夹证的治疗,可选用苓桂术甘汤、三仁汤等加减,宣降共施,寒温并用,标本兼顾,肺脾同调,以提高慢性咳嗽风咳证治疗效果。Objective To investigate the medication rules of wind cough syndrome of chronic cough and provide reference for clinical treatment.Methods In this study,a database was established based on the clinical records of cough outpatient department of Dongfang Hospital of Beijing University of Chinese Medicine and the frequency analysis of drugs was conducted.Data mining software was used to conduct association rules and cluster analysis.Results A total of 548 prescriptions were included,which involved 139 Chinese drugs.The commonly used drug category were Qi-descending and cough-relieving drugs,heat-clearing drugs,lung-dispersing and exterior-releasing drugs,dampness-resolving drugs,wind-dispersing drugs and so on.The flavors used most were pungent and bitter,and the property was warm.Most drugs belong to lung,stomach and spleen meridians.The common drug pairs are Mahuang(Ephedrae Herba)-Xuanfuhua(Inulae Flos),Yiyiren(Coicis Semen)-Baidoukou(Amomi Fructus Rotundus),Mahuang(Ephedrae Herba)-Qianhu(Peucedani Radix),Lugen(Phragmitis Rhizoma)-Baimaogen(Imperatae Rhizoma),Suzi(Perillae Fructus)-Sugeng(Perillae Caulis),Guizhi(Cinnamomi Ramulus)-Fuling(Poria)and so on.The core prescription was composed of the following drugs:Mahuang(Ephedrae Herba),Huangqin(Scutellariae Radix),Qianhu(Peucedani Radix),Houpo(Magnolia Officinalis Cortex),Ziwan(Asteris Radix Rhizoma),Kuandonghua(Farfarae Flos)and Qingfengteng(Sinomenii Caulis).Conclusion The results showed that wind cough syndrome of chronic cough has multiple pathogenesis,and the method of dispersing wind and dispersing lung is the basic treatment method.The prescription needs to take into account the complicated syndromes such as damp and heat,cold fluid and deficiency of lung and spleen,and Linggui Zhugan Decoction(苓桂术甘汤)and Sanren Decoction(三仁汤)can be used.Furthermore,we need to take into account co-application of dispersing and descending,combining cold and warm drugs,treating the root and pathological products simultaneously and regulating lung and spleen to i

关 键 词：慢性咳嗽 风咳证 用药规律 关联规则 聚类分析 

分 类 号：R256.11[医药卫生—中医内科学]