补肾活血方配合膝寸劲伸缩锻炼治疗中重度膝骨关节炎的疗效及对相关炎症因子的影响  

Efficacy of Bushen Huoxue Recipe(补肾活血方)Combined with Knee Cunjin Exercise(膝寸劲伸缩锻炼)in Treatment of Moderate and Severe Knee Osteoarthritis and The Effect of Related Inflammatory Factors

作　　者：张鑫 田天照[1,2,3] 朱秀梅 周意[1] 施敏 王俊 杨毅 刘保新[1,2,3] ZHANG Xin;TIAN Tianzhao;ZHU Xiumei;ZHOU Yi;SHI Min;WANG Jun;YANG Yi;LIU Baoxin(The Affiliated TCM Hospital of Guangzhou medical university,Guangzhou 510016,Guangdong,China;Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Guangzhou 510016,Guangdong,China;Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China)

机构地区：[1]广州医科大学附属中医医院,广东广州510016 [2]广州中医药大学附属中医医院,广东广州510016 [3]广州中医药大学,广东广州510006

出　　处：《辽宁中医杂志》2023年第6期93-95,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81774378)。

摘　　要：目的探讨补肾活血方配合膝寸劲伸缩锻炼治疗中重度膝骨关节炎(KOA)的效果及对血清白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)的影响。方法50例中重度KOA患者随机分为对照组与治疗组(各25例),对照组用艾瑞昔布、盐酸氨基葡萄糖及股四头肌收缩锻炼治疗,治疗组用补肾活血方与膝关节寸劲伸缩锻炼治疗。观察两组患者治疗前、治疗后1周与3周时膝Lysholm关节功能评分、血清IL-6及TNF-α的变化,并随访患者0.5~1年内急性疼痛的复发情况。结果治疗前,两组患者膝Lysholm评分、血清IL-6及TNF-α比较差异无统计学意义(P>0.05)。治疗1周后,两组患者膝Lysholm评分、血清IL-6与TNF-α水平与各组治疗前比较均有统计学意义(均P<0.01),且治疗组更优于对照组(均P<0.01)。治疗3周后,两组患者膝Lysholm评分、血清IL-6与TNF-α水平与治疗前、治疗1周后比较均有统计学意义(均P<0.01),且治疗组更优于对照组(P<0.01)。治疗后0.5~1年内,两组患者急性疼痛发作频次无统计学意义。结论补肾活血方配合膝寸劲伸缩锻炼治疗中重度KOA疗效显著,且可快速降低患者血清IL-6与TNF-α表达水平。Objective To explore the effect of Bushen Huoxue Recipe(补肾活血方)combined with knee Cunjin exercise in the treatment of moderate and severe knee osteoarthritis(KOA)and its effect on serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α).Methods Fifty patients with KOA were randomly divided into control group and treatment group(25 case in each).The control group was treated with adrioxib tablets,glucosamine hydrochloride capsule and quadriceps muscle contraction exercise,and the treatment group was treated with Bushen Huoxue Recipe and knee Cunjin exercise.The changes of Lysholm knee joint function score and serum levels of IL-6 and TNF-α were observed before treatment and 1 and 3 weeks after treatment,and the recurrence of acute pain was followed up for 6-12 months.Results Before treatment,there was no significant difference in knee joint function score or serum levels of IL-6 and TNF-αbetween the two groups(P>0.05).One week after treatment,the knee joint function score of the two groups was significantly improved as compared with that of each group before treatment(P<0.01),and the treatment group was superior to the control group(P<0.01).After 3 weeks of treatment,the knee joint function scores of the two groups were significantly higher than those before treatment and 1 week after treatment(P<0.01),and the treatment group was better than the control group(P<0.01).The levels of serum IL-6 and TNF-α in both groups after treatment were significantly lower than those before treatment,and the degree of decrease in the treatment group was better than that in the control group(P<0.01).Conclusion Bushen Huoxue Recipe combined with knee Cunjin exercise is effective in the treatment of KOA,and can reduce the levels of IL-6 and TNF-α in the serum.

关 键 词：膝关节骨关节炎 补肾活血方 运动疗法 细胞因子 

分 类 号：R684.3[医药卫生—骨科学]