抗雄激素药物治疗皮肤病研究进展  

Anti-androgen drugs in the treatment of skin diseases

作　　者：孙小洁 刘毅 Sun Xiaojie;Liu Yi(Clinical Trial and Cosmetics Testing Center,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]中国医学科学院,北京协和医学院皮肤病医院临床药理及化妆品检测中心,南京210042

出　　处：《中华皮肤科杂志》2023年第9期882-885,共4页Chinese Journal of Dermatology

摘　　要：雄激素是体内重要的性激素,参与多种皮肤病的发生发展,如痤疮、雄激素性脱发、多毛症等。抗雄激素药物可作用于雄激素合成途径及作用通路不同位点,拮抗雄激素作用,用于缓解并治疗相关疾病。近年来,该类药物治疗皮肤病取得一些研究进展,如克拉考特酮是近40年来首个用于痤疮局部治疗的新机制药物,度他雄胺用于治疗20岁以上男性雄激素性脱发,非那雄胺外用制剂用于雄激素性脱发和女性特发性多毛症疗效显著。本文综述近年抗雄激素药物治疗皮肤病取得的研究进展。Androgens are important sex hormones in the body,and are involved in the occurrence and development of various skin diseases,such as acne,androgenetic alopecia,hirsutism.Anti-androgen drugs can act on different sites in the androgen synthesis and functional pathways to antagonize the effects of androgens,and can be used in the alleviation and treatment of related diseases.In recent years,some research progress has been made in the treatment of skin diseases with anti-androgen drugs.For example,clascoterone is a first-in-class topical drug in the treatment of acne in the last 40 years,dutasteride can be applied in male patients aged over 20 years with androgenetic alopecia,and topical finasteride is markedly effective for the treatment of androgenetic alopecia,as well as idiopathic hirsutism in females.This review summarizes research progress in anti-androgen drugs in the treatment of skin diseases in recent years.

关 键 词：雄激素拮抗药 皮肤疾病 治疗 秃发 多毛症 痤疮 

分 类 号：R751[医药卫生—皮肤病学与性病学]