子宫内膜异位症与IVF-ET/FET后产科并发症的相关性研究  

Study on the correlation between endometriosis and obstetric complications after IVF-ET/FET

作　　者：韦兴健 周正欣 谢蕙霞 刘淼 吕群 Wei Xingjian;Zhou Zhengxin;Xie Huixia;Liu Miao;Lv Qun(Department of Obstetrics and Gynecology,School of Clinical Medicine,Southwest Medical University,Luzhou Sichuan 646099;Reproductive Center,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,Chengdu Sichuan 610072,P.R.China)

机构地区：[1]西南医科大学临床医学院妇产科,四川泸州646099 [2]四川省医学科学院·四川省人民医院生殖中心,四川成都610072

出　　处：《中国计划生育和妇产科》2023年第8期25-27,31,共4页Chinese Journal of Family Planning & Gynecotokology

基　　金：四川省妇幼保健协会妇幼医学科技创新项目(项目编号:2020ZD04)。

摘　　要：目的探讨子宫内膜异位症(endometriosis,EMs)与不孕患者行体外受精-胚胎移植/冻胚移植(in vitro fertilization-embryo transfer/frozen embryo transfer,IVF-ET/FET)后产科并发症相关性。方法回顾性分析2017年1月至2022年8月于四川省人民医院行IVF-ET/FET及分娩患者的资料。收集其中因EMs行胚胎移植助孕患者的资料,采用倾向性评分匹配(propensity score matching,PSM)的方法进行1∶1匹配(匹配容差为0.05),最终共纳入103例EMs患者为EMs组,103例非EMs患者为非EMs组。比较两组患者产科并发症及妊娠结局的差异,探讨子宫内膜异位症与产科并发症的相关性。结果EMs组前置胎盘发生率较非EMs组更高[22.33%(23/103)vs 10.68%(11/103),χ^(2)=5.07,P=0.024],而妊娠期糖尿病、妊娠期高血压疾病、胎盘植入、胎儿宫内生长受限及早产等产科并发症差异均无统计学意义(P>0.05)。结论EMs患者IVF-ET/FET后前置胎盘发生率高于非EMs患者,EMs可能是前置胎盘发生的影响因素,针对此类患者,应加强孕期监测,进行合理有效的孕期指导。Objective To investigate the correlation between obstetric complications and endometriosis in infertile patients after in vitro fertilization-embryo transfer/frozen embryo transfer(IVF-ET/FET).Methods Data of patients who received IVF-ET/FET and delivery in Sichuan Provincial People's Hospital from January 2017 to August 2022 were retrospectively analyzed.The data of the patients who received embryo transfer for EMs were collected,and the propensity score matching method was used for 1∶1 matching(matching tolerance was 0.05).A total of 103 EMs patients were enrolled as the EMs group,and 103 patients without EMs as the non-EMs group.The differences of obstetric complications and pregnancy outcomes between the two groups were compared,and the correlation between endometriosis and obstetric complications was discussed.Results The incidence of placenta previa in EMs group was higher than that in non-EMs group[22.33%(23/103)vs 10.68%(11/103),χ^(2)=5.07,P=0.024],but there were no significant differences in obstetric complications such as gestational diabetes mellitus,hypertensive disorders of pregnancy,placenta accreta,intrauterine growth restriction and preterm birth(P>0.05).Conclusion The incidence of placenta previa in patients with endometriosis after IVF-ET/FET is higher than that in patients without endometriosis.EMs may be an infcuence factor for increasing the risk of placenta previa.For such patients,pregnancy monitoring should be strengthened and reasonable and effective pregnancy guidance should be carried out.

关 键 词：子宫内膜异位症 胚胎移植 产科并发症 倾向性评分 

分 类 号：R711.6[医药卫生—妇产科学]