基于斑马鱼模型的中药抗骨质疏松的研究进展  

Research progress on anti-osteoporosis of traditional Chinese medicine based on zebrafish model

作　　者：王璇 陈林珍 林瑞超[1] 陶晓宇 于雪[2] 张淑静[2] 范琦琦 李芝奇 戴胜云 李向日[1] 赵崇军[1] WANG Xuan;CHEN Lin-zhen;LIN Rui-chao;TAO Xiao-yu;YU Xue;ZHANG Shu-jing;FAN Qi-qi;LI Zhi-qi;DAI Sheng-yun;LI Xiang-ri;ZHAO Chong-jun(Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China;Beijing University of Chinese Medicine,Beijing 102488,China;National Institutes for Food and Drug Control,Beijing 102629,China)

机构地区：[1]北京中医药大学中药品质评价北京市重点实验室,北京102488 [2]北京中医药大学,北京102488 [3]中国食品药品检定研究院,北京102629

出　　处：《中草药》2023年第15期5088-5100,共13页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82204753);国家科技重大专项(2018ZX09735005);国家中医药管理局公益性中医药行业科研专项(201507004)。

摘　　要：骨质疏松症(osteoporosis,OP)是一种以骨密度降低、骨骼微结构改变和骨质脆弱增加为特征的骨骼疾病。由于老龄化问题的逐渐加重,OP的发病率在全球范围内迅速增加。中药在预防和治疗OP中表现出极好的前景和临床效果,然而传统动物模型具有耗时长、费用昂贵、无法准确概括骨疾病复杂性等缺点,很大程度上限制了临床前OP疾病的研究进程。而斑马鱼模型可有效模拟人类骨质减少和OP表型,通过对斑马鱼模型在治疗OP研究中的优势和适用性及该模型在中药抗OP的研究进展进行综述,为斑马鱼模型的广泛使用及中药新药研发提供参考。Osteoporosis is a bone disease characterized by decreased bone density,changes in bone microstructure,and increased bone fragility.Due to the increasing aging problem,the incidence of osteoporosis is increasing rapidly around the world.Traditional Chinese medicine has shown excellent prospects and clinical effects in the prevention and treatment of osteoporosis.However,traditional animal models have disadvantages of time-consuming,high cost and inability to accurately summarize the complexity of bone diseases,which greatly limits the research process of preclinical osteoporosis diseases.The zebrafish model can effectively simulate the human osteopenia and osteoporosis phenotype.The advantages and applicability of zebrafish model in the treatment of osteoporosis and the research progress of this model in the anti-osteoporosis of Chinese medicine were reviewed,with view to providing references for the widespread use of zebrafish model and the development of new Chinese medicine drugs.

关 键 词：斑马鱼 骨质疏松 中药 药对 中药复方 药物筛选 

分 类 号：R285[医药卫生—中药学]