桑叶化学成分与药理作用研究进展及其质量标志物预测分析  

Predictive studies of quality markers in Mori Folium based on chemical constituents and pharmacological mechanism

作　　者：林闪闪 王梦娇 许金国[1] 皮文霞[1] 潘林梅[1] 毛春琴 陆兔林[1] LIN Shan-shan;WANG Meng-jiao;XU Jin-guo;PI Wen-xia;PAN Lin-mei;MAO Chun-qin;LU Tu-lin(College of Pharmaceutical Science,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院,江苏南京210023

出　　处：《中草药》2023年第15期5112-5127,共16页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划资助项目(2018YFC1707000)。

摘　　要：传统大宗中药材桑叶具有多种药用价值及保健功效,是我国首批认定的药食同源品种。其量产区主要于广东、广西、安徽、重庆、云南等地,国内外学者对桑叶的化学成分、药理机制等分别开展了大量的研究。传统上桑叶的功效包括疏散风热、清肺润燥、平肝明目、凉血止血;现代研究显示其主要药效包括抗炎镇痛、调节血糖等,主要效应成分有生物碱、黄酮、多糖类等化合物。从桑叶资源分布、化学成分、药理机制等分析近10年研究成果,对其质量标志物进行预测分析,探讨可表征其质量的成分指标与药理作用的内在关联性,为桑叶饮片的质量评价及临床应用研究提供科学依据。Sangye(Mori Folium),a traditional Chinese medicine(TCM)with a variety of medicinal value and health function,it is the first batch of food and medicine homologous varieties of TCM in China.Its resources are widely distributed,and the production areas are mainly in Guangdong,Guangxi,Anhui,Chongqing,Yunnan and other places.A lot of studies on chemical constituents and pharmacological mechanisms of Mori Folium have been carried out by scholars at home and abroad.The traditional effects of Mori Folium include dispersing wind and heat,clearing lungs and moistening dryness,pacifying liver and eyesight,cooling blood and stopping bleeding,the modern research shows that its main effects include anti-inflammatory,analgesic,and hypoglycemic.The main effective components conclude alkaloids,flavonoids and polysaccharides etc.In this paper,from studying the literature in the past 10 years,we analyze the results of its separation,detection,action mechanism in Mori Folium,in order to make a scientific prediction of its Q-Marker,analyze the internal relationship between the composition index and action mechanisms,so we could provide a scientific basis for the research of quality evaluation and clinical application of Mori Folium.

关 键 词：桑叶 生物碱 黄酮 多糖 抗炎 调节血糖 质量标志物 预测分析 

分 类 号：R286[医药卫生—中药学]