激肽B1受体水平对T2DM患者心血管不良事件风险的预测价值  

The value of kinin B1 receptor levels in predicting the risk of cardiovascular adverse events in patients with type 2 diabetes mellitus

作　　者：王蕊[1] 王翠娟[1] 刘佳 张萌萌[1] 王佳美 王锐[1] WANG Rui;WANG Cuijuan;LIU Jia;ZHANG Mengmeng;HAN Gailing;YIN Fuzai;LU Qiang;MA Chunming;WANG Jiamei;WANG Rui(First Hospital of Qinhuangdao,Qinhuangdao Hebei 066000,China)

机构地区：[1]秦皇岛市第一医院,河北秦皇岛066000 [2]秦皇岛市第二医院,河北秦皇岛066000

出　　处：《中国急救复苏与灾害医学杂志》2023年第9期1135-1138,1184,共5页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：河北省卫健委2020年度医学科学研究项目(编号:20201512);河北省秦皇岛科学技术研究与发展计划项目(编号:202004A133);河北省秦皇岛科学技术研究与发展计划项目(编号:HO.202301A204)。

摘　　要：目的探讨激肽B1受体(B1R)水平预测2型糖尿病(T2DM)患者心血管不良事件风险的价值。方法入选2018年6月-2019年12月于秦皇岛市第一医院就诊的189例T2DM患者为研究对象。患者就诊时测量B1R水平,记录随访2年患者心血管不良事件发生情况,根据患者是否发生心血管不良事件分为发生组和未发生组,并采用多因素Logistic回归方程分析B1R水平与T2DM患者心血管不良事件风险的相关性。结果截至末次随访日期2021年12月19日,189例患者中共163例完成随访,其中48例发生心血管不良事件(发生组),未发生心血管不良事件的115例患者为未发生组,比较两组患者临床资料发现,发生组T2DM病程、体重指数(BMI)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(2hPBG)、B1R、总胆固醇(TG)、低密度脂蛋白(LDL)水平与未发生组比较差异有统计学意义(均P<0.05);多因素Logistic回归分析显示T2DM病程(OR=2.691)、BMI(OR=1.346)、HbA1c(OR=2.088)、B1R水平(OR=4.315)、TG(OR=1.261)、LDL(OR=2.401)是T2DM患者心血管不良事件发生的危险因素(P<0.05)。进一步应用受试者工作特征(ROC)曲线分析显示,高B1R水平预测T2DM患者心血管不良事件风险的曲线下面积为0.855,Delong法比较结果显示,B1R水平ROC曲线下面积明显大于T2DM病程、BMI、HbA1c、TG及LDL。结论高B1R水平是T2DM患者心血管不良事件的风险因素,临床治疗过程中应重点关注B1R水平。Objective To investigate the value of kinin B1 receptor(B1R)levels in predicting the risk of cardiovascular events in patients with type 2 diabetes mellitus(T2DM).Methods 189 patients with T2DM who were treated in our hospital from June 2018 to January 2019 were as the research objects.The B1R level was measured at the time of consultation,and the patients were followed up for 2 years.The occurrence of cardiovascular events was recorded.The patients were divided into occurrence group and non-occurring group according to whether a cardiovascular event occurred.Multivariate logistic regression equation was used to analyze the relevance between B1R level and cardiovascular event risk in T2DM patients.Results As of the last follow-up date,December 19,2021,a total of 163 patients from 189 patients had completed the follow-up,of which 48 patients had cardiovascular adverse events(the occurrence group),and 115 patients without cardiovascular adverse events were the non occurrence group.By comparing the clinical data of patients from the two groups,it was found that T2DM course,BMI,HbA1c,FBG,2hPBG,B1R,TG,LDL was significantly higher than that of the control group(all P<0.05).Multivariate logistic regression analysis showed that the course of T2DM(OR=2.691),BMI(OR=1.346),HbA1c(OR=2.088),B1R level(OR=4.315),TG(OR=1.261),LDL(OR=2.401)were the risk factors for adverse cardiovascular events in T2DM patients(P<0.05).Further analysis of the ROC curve of the subjects showed that the area under the curve of high B1R level predicting the risk of cardiovascular adverse events in T2DM patients was 0.855.The Delong method showed that the area under the ROC curve of B1R level was significantly larger than that of T2DM duration,BMI,HbA1c,TG and LDL.Conclusion High B1R level is a risk factor for cardiovascular adverse events in patients with T2DM,and B1R level should be paid attention to during clinical treatment.

关 键 词：激肽B1受体 2型糖尿病 心血管不良事件 相关性 

分 类 号：R587.1[医药卫生—内分泌]