板蓝根苯丙素糖苷成分研究  

Study on Phenylpropanin Glycosides From Isatisin digotica Fort

作　　者：陆正阳 罗美琪 曾文丽 陈玉[1] 杨光忠[2] Lu Zhengyang;Luo Meiqi;Zeng Wenli;Chen Yu;Yang Guangzhong(College of Chemistry and Material Sciences,South-Central Minzu University,Wuhan,Hubei 430074,China;School of Pharmaceutical Sciences,South-Central Minzu University,Wuhan,Hubei 430074,China)

机构地区：[1]中南民族大学化学与材料科学学院,湖北武汉430074 [2]中南民族大学药学院,湖北武汉430074

出　　处：《绿色科技》2023年第14期204-210,共7页Journal of Green Science and Technology

基　　金：湖北省重点研发项目(编号:2021ACB003)。

摘　　要：为研究板蓝根中苯丙素糖苷类化学成分,采用大孔吸附树脂D101、正、反相硅胶柱色谱以及半制备型高效液相色谱等技术分离纯化其乙醇提取物,结合多种现代波谱技术及量子化学计算鉴定化合物的结构,从板蓝根乙醇提取物中分离出13个苯丙素糖苷类化合物,其结构分别鉴定为isatisoside A(1),ceplignan-4-O-β-D-glucoside(2),isatioxyneolignoside E(3),isatioxyneolignoside F(4),lariciresinol-4'-O-β-D-glucopyranoside(5),lariciresinol-9-O-β-D-glucopyranoside(6),conoicaoside(7),medioresinol di-O-β-D-glucopyranoside(8),顺紫丁香苷(9),紫丁香苷(10),(Z)-coniferin(11),coniferin(12),1-feruloyl-O-β-D-glucopyranoside(13)。化合物2,7,8为首次从板蓝根中分离得到,化合物1为新化合物,命名为isatisoside A。In order to study the chemical composition of phenylpropanin glycosides from Isatis indigotica Fort,the ethanol extract was separated and purified by macroporous adsorption resin D101,normal and reversed-phase column chromatography,and semi-preparative HPLC.Combined with a variety of modern spectral techniques and quantum chemical calculations,thirteen phenylpropanin glycosides were isolated and identified from I.indigotica.Their structures were identified as isatisoside A(1),ceplignan-4-O-β-D-glucoside(2),isatioxyneolignoside E(3),isatioxyneolignoside F(4),lariciresinol-4'-O-β-D-glucopyranoside(5),lariciresinol-9-O-β-D-glucopyranoside(6),conoicaoside(7),medioresinol di-O-β-D-glucopyranoside(8),(Z)-syringin(9),syringin(10),(Z)-coniferin(11),coniferin(12)and 1-feruloyl-O-β-D-glucopyranoside(13).Compounds 2,7,and 8 were isolated from I.indigotica for the first time,and isatisoside A(compound 1)was new.

关 键 词：板蓝根 化学成分 苯丙素 木脂素 

分 类 号：R284[医药卫生—中药学]