四氧嘧啶建立1型DM动物模型研究进展  

Research progress in establishing the animal model of type 1 DM with alloxan

作　　者：周海东 罗昌泰 稂宇嘉 韦积华[2] 周俊秀 玉蓝青 ZHOU Haidong;LUO Changtai;LANG Yujia;WEI Jihua;ZHOU Junxiu;YU Lanqing(Youjiang Medical University for Nationalities,Guangxi,Baise 533000,China;Department of Sports Medicine,Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi,Baise 533000,China;Baise Maternity and Child Health Care Hospital,Guangxi,Baise 533000,China)

机构地区：[1]右江民族医学院,广西百色533000 [2]右江民族医学院附属医院运动医学科,广西百色533000 [3]广西百色市妇幼保健院,广西百色533000

出　　处：《中国医药科学》2023年第16期25-28,59,共5页China Medicine And Pharmacy

基　　金：国家自然科学基金(82260887);广西自然科学基金(2020GXNSFAA259068);右江民族医学院附属医院第一批高层次人才科研项目(R20196321);右江民族医学院研究生创新计划项目(YZCXJH2022004)。

摘　　要：糖尿病(DM)是临床上的常见病及多发病,关于DM的基础研究依然是目前的研究热点。四氧嘧啶为构建DM模型常用药物,是DM基础研究的关键环节。国内外报道其成模率较低,成模后造成多组织损伤,使实验结果产生偏倚。本文总结近年构建DM模型采用的剂量及对各组织的损害,为DM基础实验提供适宜造模剂量及降低实验误差提供理论依据。Diabetes mellitus(DM)is a common and frequently occurring disease in clinic,and the basic research on DM is still a research highlight at present.As a commonly used medicine to construct DM models,alloxan is a key link in the basic research of DM.It has been reported at home and abroad that the molding rate is relatively low,and it may cause multiple tissue damage after molding,resulting in biased experimental results.In this paper,the dosage used to construct DM models and the damage of alloxan to various tissues in recent years are summarized,so as to provide a theoretical basis for appropriate modeling dosage for DM basic experiments and for reducing experimental errors.

关 键 词：糖尿病 四氧嘧啶 动物模型 机制 

分 类 号：R587.1[医药卫生—内分泌]