芪丹舒心汤联合瑞舒伐他汀钙治疗冠心病伴高脂血症的效果分析  

Effect analysis of Qidan Shuxin Decoction combined with rosuvastatin calcium in the treatment of coronary heart disease with hyperlipidemia

作　　者：张永升 ZHANG Yong-sheng(Internal Medicine Department,The Second Hospital of Traditional Chinese Medicine of Tai'an City,Tai'an 271000,China)

机构地区：[1]泰安市中医二院中医内科,271000

出　　处：《中国实用医药》2023年第17期112-115,共4页China Practical Medicine

摘　　要：目的 探析冠心病伴高脂血症患者经芪丹舒心汤联合瑞舒伐他汀钙治疗的效果。方法 104例冠心病伴高脂血症患者,经盲选法分为对照组和观察组,每组52例。对照组患者采取瑞舒伐他汀钙治疗,观察组患者采取瑞舒伐他汀钙联合芪丹舒心汤治疗。比较两组患者治疗前后血脂指标(总胆固醇、甘油三酯)水平,治疗前后西雅图心绞痛量表(SAQ)评分、中医证候量表(TCM)评分,临床效果,治疗安全性,治疗前后炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平。结果 治疗前,两组患者的总胆固醇、甘油三酯水平比较差异无统计学意义(P>0.05);治疗后,两组患者的总胆固醇、甘油三酯水平均低于治疗前,且观察组患者的总胆固醇(3.71±0.49)mmol/L、甘油三酯(1.30±0.52)mmol/L均低于对照组的(4.48±0.35)、(1.69±0.47)mmol/L,差异有统计学意义(P<0.05)。治疗前,两组患者的SAQ评分、TCM评分比较差异无统计学意义(P>0.05);治疗后,两组患者的SAQ评分高于治疗前、TCM评分低于治疗前,且观察组患者的SAQ评分(79.25±7.43)分高于对照组的(70.95±7.17)分、TCM评分(11.76±1.25)分低于对照组的(16.32±1.42)分,差异具有统计学意义(P<0.05)。观察组总有效率为96.2%,高于对照组的76.9%,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率为7.7%,低于对照组的23.1%,差异具有统计学意义(P<0.05)。治疗前,两组患者的IL-6、CRP、TNF-α水平比较差异无统计学意义(P>0.05);治疗后,两组患者的IL-6、CRP、TNF-α水平均低于治疗前,且观察组患者的IL-6(8.07±2.61)ng/L、CRP(3.02±1.19)mg/L、TNF-α(0.68±0.55)ng/L均低于对照组的(14.19±2.79)ng/L、(4.32±1.59)mg/L、(1.03±0.42)ng/L,差异具有统计学意义(P<0.05)。结论 冠心病伴高脂血症患者经芪丹舒心汤联合瑞舒伐他汀钙治疗的疗效明显,对血脂、心绞痛等改善效果理想,可降低机体炎症反应,�Objective To discuss the effect of Qidan Shuxin Decoction combined with rosuvastatin calcium in the treatment of coronary heart disease with hyperlipidemia.Methods A total of 104 patients with coronary heart disease and hyperlipidemia were divided into control group and observation group by blind selection,with 52 cases in each group.The control group was treated with rosuvastatin calcium,and the observation group was treated with rosuvastatin calcium and Qidan Shuxin Decoction.Both groups were compared in terms of levels of blood lipid indexes(total cholesterol and triglycerides),the score of Seattle angina questionnaire(SAQ)and traditional Chinese medicine(TCM)syndrome score before and after treatment,the clinical effect,treatment safety,levels of inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]before and after treatment.Results Before treatment,there was no statistically significant difference in levels of total cholesterol and triglyceride between the two groups(P>0.05).After treatment,the levels of total cholesterol and triglyceride in both groups were lower than those before treatment in this group;the total cholesterol of(3.71±0.49)mmol/L and triglyceride of(1.30±0.52)mmol/L in the observation group were lower than those of(4.48±0.35)and(1.69±0.47)mmol/L in the control group;the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in SAQ score and TCM syndrome score between the two groups(P>0.05).After treatment,SAQ score was higher than that before treatment in this group,and TCM syndrome score was lower than that before treatment in this group;SAQ score of(79.25±7.43)points in the observation group was higher than that of(70.95±7.17)points in the control group;TCM syndrome score of(11.76±1.25)points in the observation group was lower than that of(16.32±1.42)points in the control group;the differences were statistically significant(P<0.05).The total effective rate of the observation g

关 键 词：芪丹舒心汤 瑞舒伐他汀钙 冠心病 高脂血症 效果 

分 类 号：R541.4[医药卫生—心血管疾病] R589.2[医药卫生—内科学]