广西壮族人群出生队列的构建和研究进展  

Construction and research progress of Guangxi Zhuang Birth Cohort

作　　者：仇小强[1] 黄东萍[1] 黄荟深 Qiu Xiaoqiang;Huang Dongping;Huang Huishen(School of Public Health,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学公共卫生学院,南宁530021

出　　处：《广西医科大学学报》2023年第8期1259-1266,共8页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.B1460517);广西重点研发计划资助项目(No.桂科AB17195012)。

摘　　要：随着我国经济社会的发展和生育政策的改变,社会生态环境不断变化,生命早期不良暴露日益增加,我国孕产妇发生妊娠疾病及新生儿不良出生结局形势依然严峻。多哈理论认为,生命早期发生的不良事件可能会影响成年后各类疾病的发生,这种影响甚至会持续好几代人。出生队列主要是在孕前或孕期招募参与者,对孕产期母亲健康与子代近远期健康结局进行跟踪随访,进而发现影响全生命周期健康结局的多种因素,检验病因假说。目前国内已有不少具有相当规模的出生队列,但其大多数主要面向汉族人群。我国是一个多民族国家,许多疾病的发生具有地域和民族分布特点,壮族是我国人口最多的少数民族,但目前关于壮族人群的大型流行病学调查十分有限,无法系统概括壮族人群和壮族母婴健康特点,提出面向壮族人群不良健康结局的有效防治措施。因此,有必要建立一个以壮族人群为主体的大规模出生队列,系统描绘壮族人群和壮族母婴健康特点,探索生命早期暴露与孕妇及子代近远期健康结局的关系,为有效降低壮族人群不良健康结局的发生风险,提高出生人口素质和促进妇女儿童健康水平提供重要依据。本文系统介绍了广西壮族人群出生队列构建的背景、过程、主要研究进展、创新性以及未来展望。With the development of economy and society in China,the change of fertility policy,the changing social ecological environment,and the increasing exposure to adverse events in early life,the situation of pregnancy diseases and adverse birth outcomes in China is still severe.According to Dohah theory,adverse events that occur in early life may affect the occurrence of various diseases in adulthood,and this effect may even last for several generations.The birth cohort is mainly recruited among women before or during pregnancy to involve participants.The maternal health during pregnancy and the short-and long-term health outcomes of offspring are followed up,so as to find a variety of factors affecting overall lifecycle health outcomes and test the etiological hypothesis.At present,there are many birth cohorts with considerable size in China,but most of them are mainly for Han population.China is a multiethnic country,and the occurrence of many diseases has the characteristics of regional and ethnic distribution.Zhuang nationality is the most populous ethnic minority in China.However,the large-scale epidemiological survey on Zhuang population is very limited,so it is difficult to systematically summarize the health characteristics of Zhuang population,maternal and child health,and to provide effective prevention and control measures for adverse health outcomes in Zhuang population.Therefore,it is necessary to establish a large-scale birth cohort of Zhuang population,systematically describing the health characteristics of Zhuang population,maternal and child health,and exploring the relationship between early life exposure during childbirth and short-and long-term health outcomes of pregnant women and their offspring,so as to provide important evidence for effectively reducing the risk of adverse health outcomes in Zhuang population,improving the quality of birth population,and promoting the health of women and children.This paper systematically introduces the construction background,process,major research progress,i

关 键 词：壮族 出生队列 队列构建 研究进展 

分 类 号：R18[医药卫生—流行病学]