中医药多靶点治疗慢性阻塞性肺疾病机制的研究概论  

Mechanism of TCM Multi-target Treatment of Chronic Obstructive Pulmonary Disease

作　　者：徐梦娇 晏军[2] 张迪 李莉[2] XU Mengjiao;YAN Jun;ZHANG Di;LI Li(Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]中国中医科学院望京医院,北京100102 [2]北京中医药大学东直门医院,北京100700

出　　处：《世界中医药》2023年第16期2396-2401,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(82205036)。

摘　　要：慢性阻塞性肺疾病(COPD)是一种以持续气流受限为特征,以慢性咳嗽、咳痰、气短、喘息等为主要临床表现的常见病。COPD因肺功能进行性减退,严重影响患者的劳动力和生命质量。由于环境污染加重、吸烟等因素的影响,COPD的患病率和死亡率呈不断上升趋势。中医药治疗疾病具有整体性和全面性的特点,在防治COPD方面取得了良好的成果。中医药通过抑制气道炎症反应、缓解氧化应激、减轻气道黏液高分泌、抑制蛋白酶/抗蛋白酶失衡、延缓肺衰老、降低气道高糖,发挥多通路、多靶点干预的特点。但目前仍存在以下不足:大量动物实验只进行对病治疗,缺乏对证治疗的研究;实验造模存在差异,影响相同机制调控下药物疗效对比;临床试验检测指标相似,缺乏创新性;临床试验以单中心的小样本研究为主,循证医学证据等级较低。因此,在未来的研究中应充分利用现代科学技术进行多学科的交叉,深入挖掘中医药干预COPD的作用机制。Chronic obstructive pulmonary disease(COPD)is a common condition characterized by persistent airflow limitation,with chronic cough,expectoration,shortness of breath,and wheezing as its main clinical manifestations.COPD is associated with progressive decline in lung function,significantly affecting patients′work capacity and quality of life.Due to factors such as increased environmental pollution and smoking,the incidence and mortality rates of COPD are continuously rising.Traditional Chinese medicine(TCM)has achieved good results in the prevention and treatment of COPD due to its holistic and comprehensive characteristics.TCM intervenes in COPD through multiple pathways and targets,including inhibiting airway inflammation,relieving oxidative stress,reducing excessive airway mucus secretion,restoring the balance between proteases and antiproteases,delaying lung aging,and lowering airway hyperglycemia.However,there are still some limitations in current research.Specifically,a large number of animal experiments focus only on disease treatment,lacking studies on syndrome-based treatment.Experimental modeling varies,which affects the comparison of drug efficacy under the same mechanism.Clinical trials use similar testing indicators,lacking innovation.Moreover,most clinical trials are small-scale,single-center studies,resulting in low levels of evidence in evidence-based medicine.Therefore,in future research,modern scientific and technological advancements should be fully utilized to facilitate multidisciplinary approaches and explore the mechanisms of TCM intervention in COPD more comprehensively.

关 键 词：慢性阻塞性肺疾病 发病机制 多靶点 中医药 综述 

分 类 号：R256.14[医药卫生—中医内科学] R563[医药卫生—中医学]