6%羟乙基淀粉130/0.4对骨折创伤兔子血清白蛋白、微血管白蛋白渗漏、炎性因子的影响  

Effects of 6% Hydroxyethyl Starch 130/0.4 on Serum Albumin,Microalbumin Leakage and Inflammatory Factors in Rabbits with Fracture Trauma

作　　者：吕洪锦 姜楠 姚克石 张倩 张建中[3] Lyu Hongjin;Jiang Nan;Yao Keshi;Zhang Qian;Zhang Jianzhong(Longkou People's Hospital1,Yantai 265700,Shandong Province,China;The Second School of Clinical Medicine of Binzhou Medical University,Yantai 264000,Shandong Province,China;Yantaishan Hospital,Yantai 264000,Shandong Province,China)

机构地区：[1]龙口市人民医院,山东烟台265700 [2]滨州医学院第二临床医学院,山东烟台264000 [3]烟台市烟台山医院,山东烟台264000

出　　处：《中国社区医师》2023年第24期8-10,共3页Chinese Community Doctors

基　　金：山东省自然科学基金(编号:ZR2022MH320);滨州医学院“临床+X”科技创新项目(编号:BY2021LCX35)。

摘　　要：目的:探讨6%羟乙基淀粉(HES)130/0.4对骨折创伤兔子血清白蛋白、微血管白蛋白渗漏、炎性因子的影响。方法:将20只健康雌性大白兔随机分为模型组和HES组,各10只,均采用钝器敲打后肢造成后肢骨折,行骨折切开内固定术。术后,模型组注射10 m L/kg生理盐水,HES组注射10 m L/kg 6%HES 130/0.4,连续3 d。比较两组血清白蛋白水平、微血管白蛋白渗漏情况以及白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)水平。结果:术后72 h,两组血清白蛋白水平低于术前,但HES组高于模型组,差异有统计学意义(P<0.05);HES组肠系膜微血管白蛋白渗漏率低于模型组,差异有统计学意义(P<0.05);两组血清IL-6、CRP以及PCT水平高于术前,但HES组低于模型组,差异有统计学意义(P<0.05)。结论:骨折创伤兔子术后存在血清白蛋白水平下降、炎性因子水平升高情况,给予6%HES 130/0.4治疗可以减小血清白蛋白降低幅度,下调IL-6、CRP以及PCT水平,改善白蛋白渗漏情况。Objective:To explore the effects of 6% hydroxyethyl starch 130/0.4(HES) on the serum albumin,microalbuminleakage and inflammatory factors in rabbits with fracture trauma.Methods:Twenty healthy female white rabbits were randomlydivided into model group and HES group,with 10 rabbits in each group.In all rabbits,hind limb fractures were made by beat withblunt instruments,and fracture open and internal fixation were performed.After surgery,the model group was injected with 10 m L/kg normal saline,and the HES group was injected with 10 m L/kg HES,for 3 successive days.The serum albumin levels,microalbumin leakage,and interleukin-6(IL-6),C-reactive protein(CRP),and procalcitonin(PCT) levels were comparedbetween the two groups.Results:At 72 h after surgery,serum albumin levels in the two groups were lower than those beforesurgery,but the HES group was higher than the model group,and the difference was statistically significant(P<0.05).The rate ofmesenteric microalbumin leakage in the HES group was lower than that in the model group,and the difference was statisticallysignificant(P<0.05).The serum IL-6,CRP and PCT levels in the two groups were higher than those before surgery,but the HESgroup was lower than the model group,and the difference was statistically significant(P<0.05).Conclusion:There is a decrease inserum albumin level and an increase in inflammatory factor levels in fracture trauma rabbits after surgery,and HES treatment canreduce the decrease of serum albumin,down-regulate the levels of IL-6,CRP and PCT,and improve albumin leakage.

关 键 词：6%羟乙基淀粉130/0.4 骨折 兔子 微血管白蛋白渗漏 

分 类 号：R683[医药卫生—骨科学]