肌腱组织工程支架生物材料与孔隙特征  

Biomaterials and pore characteristics of tendon tissue engineering scaffolds

作　　者：王晓龙 黄浩然 张忠欣 王丽敏 胡永成[3] Wang Xiaolong;Huang Haoran;Zhang Zhongxin;Wang Limin;Hu Yongcheng(Chengyang District People’s Hospital,Qingdao 266109,Shandong Province,China;Beijing Wonderful Biotechnology Co.,Ltd.,Beijing 101100,China;Tianjin Hospital,Tianjin 300202,China)

机构地区：[1]青岛市城阳区人民医院,山东省青岛市266109 [2]北京市威达峰生物科技公司,北京市101100 [3]天津市天津医院,天津市300202

出　　处：《中国组织工程研究》2024年第15期2398-2403,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:随着肌腱损伤肌腱移植手术的增多,对肌腱组织工程支架的需求日益增加,研究发现植入物良好的孔隙大小及孔隙率有助于组织愈合。目的:总结肌腱组织工程支架的材料种类,调查各类肌腱组织工程支架材料与孔隙的相关情况。方法:应用计算机检索PubMed、Embase、Web of Science数据库中发表的相关文献,检索关键词为“tendon”或“ligament”和“tissue scaffold”以及“porosity”或“permeability”,共纳入84篇符合标准的文献进行归纳总结,讨论并展望未来的发展方向。结果与结论:肌腱组织工程研究所涉及的支架材料主要分为天然肌腱支架材料和人工合成腱性支架材料两大类,其中天然支架材料包含自体肌腱、同种异体肌腱和异种肌腱,自体肌腱、同种异体肌腱在临床上已应用多年,在制备异体肌腱以及动物实验过程中发现脱细胞消毒过程中会导致两种肌腱孔隙大小及孔隙率增加的现象,但是具体原因及机制并未进一步研究。人工合成腱性支架材料目前研究的种类有很多,其中以Leeds Keio、LARS为代表的人工韧带产品目前还在部分国家使用,其他材料目前因技术不成熟等问题未能在临床推广,人工合成腱性支架材料的孔隙及孔隙率因其材料与制备技术的不同也呈现不同的趋势。BACKGROUND:With the increasing number of tendon transplantation surgeries for tendon injuries,the demand for tendon tissue engineering scaffolds is increasing.Research has found that good pore size and porosity of implants contribute to tissue healing.OBJECTIVE:To review the types of materials currently published for tendon tissue engineering scaffolds and investigate the correlation between various tendon tissue engineering scaffold materials and pores.METHODS:Articles were retrieved on PubMed,Embase,and Web of Science databases,using keywords“tendon”or“ligament”and“tissue scaffold”as well as“porosity”or“permeability”.A total of 84 articles meeting the criteria were included to summarize,discuss and anticipate future development directions.RESULTS AND CONCLUSION:The materials used in the research of tendon tissue engineering are mainly divided into two categories:natural tendon scaffold materials and artificial synthetic tendon scaffold materials.Natural scaffold materials include autologous tendons,allogeneic tendons,and xenogeneic tendons.Autogenous tendons and allogeneic tendons have been used in clinical practice for many years.During the preparation of allogeneic tendons and animal experiments,it was found that the process of acellular disinfection resulted in an increase in the pore size and porosity of both types of tendons,but the specific reasons and mechanisms have not been further studied.There are many types of artificial tendon scaffold materials currently being studied,among which artificial ligament products such as Leeds Keio and LARS(Ligament Advanced Reinforcement System)are still in use in some countries.Other materials have not been promoted in clinical practice due to immature technology and other issues.The pores and porosity of artificial tendon scaffold materials also show different trends due to their different materials and preparation techniques.

关 键 词：生物材料支架 肌腱组织工程 肌腱支架 渗透性 孔隙率 腱骨愈合 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R-1