纳米复合水凝胶在骨关节炎治疗中的优势与特征  

Advantages and features of nanocomposite hydrogel in treatment of osteoarthritis

作　　者：田林灵 郭海瑞 杜晓明 冯杰 张宪哲 张文彬 孙浩然 张晓彬 王静霞[2] 胡一梅[1,3] 王毅[4] Tian Linling;Guo Hairui;Du Xiaoming;Feng Jie;Zhang Xianzhe;Zhang Wenbin;Sun Haoran;Zhang Xiaobin;Wang Jingxia;Hu Yimei;Wang Yi(Chengdu University of Traditional Chinese Medicine,Chengdu 610041,Sichuan Province,China;Sichuan Atomic Energy Research Institute,Chengdu 610199,Sichuan Province,China;Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610041,Sichuan Province,China;Southwest Jiaotong University,Chengdu 610031,Sichuan Province,China)

机构地区：[1]成都中医药大学,四川省成都市6100414 [2]四川省原子能研究院,四川省成都市610199 [3]成都中医药大学附属医院,四川省成都市610041 [4]西南交通大学,四川省成都市610031

出　　处：《中国组织工程研究》2024年第15期2410-2415,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(325021015),项目负责人:胡一梅;成都中医药大学科技处(030058047,030038164),项目负责人:胡一梅;成都中医药大学附属医院科研能力提升“百人计划”(22-B07),项目负责人:胡一梅;四川省科技厅国际合作项目(2020YFH0052),项目负责人:王毅;中央高校基本科研业务费项目(2682022ZTPY038),项目负责人:王毅。

摘　　要：背景:纳米复合水凝胶在骨关节炎治疗中有很大的研究前景和应用潜力。目的:综述纳米复合水凝胶在骨关节炎及软骨修复中的研究进展。方法:检索中国知网和PubMed等数据库,英文检索词为“nanocomposite hydrogel,nanogel,osteoarthritis,cartilage,physical encapsulation,electrostatic interaction,covalent crosslinking”,中文检索词为“纳米复合水凝胶,纳米水凝胶,骨关节炎,软骨,物理包覆,物理包载,静电作用,共价交联”。根据纳入与排除标准对所有文章进行初筛后,保留相关性较高的71篇文章进行综述。结果与结论:在细胞或动物实验中,纳米复合水凝胶具有改善骨关节炎的效果。纳米复合水凝胶可以从改善关节间力学环境、搭载靶向药物、促进种子细胞软骨化等方面加速软骨修复,改善骨关节炎症内环境,达到治疗骨关节炎的目的。目前纳米复合水凝胶在骨关节炎疾病中的研究仍有巨大的发挥空间,继续深入材料制备研究,积极开展细胞、动物实验将有望为临床治疗骨关节炎开辟新途径。BACKGROUND:Nanocomposite hydrogel has great research prospects and application potential in the treatment of osteoarthritis.OBJECTIVE:To review the research progress of nanocomposite hydrogel in osteoarthritis and cartilage repair.METHODS:Databases such as CNKI and PubMed were searched.The English key words were“nanocomposite hydrogel,nanogel,osteoarthritis,cartage,physical encapsulation,electrostatic interaction,covalent crosslinking”,and the Chinese key words were“nanocomposite hydrogel,nanogel,osteoarthritis,cartage,physical encapsulation,physical encapsulation,electrostatic effect,covalent cross-linking”.After an initial screening of all articles based on inclusion and exclusion criteria,71 articles with high correlation were retained for review.RESULTS AND CONCLUSION:In cell or animal experiments,nanocomposite hydrogel has the effect of improving osteoarthritis.Nanocomposite hydrogel can promote cartilage repair,improve the internal environment of osteoarthritis,and achieve the therapeutic purpose of osteoarthritis by improving the mechanical environment between joints,carrying targeted drugs,and promoting the chondrogenesis of seed cells.At present,the research of nanocomposite hydrogel in osteoarthritis disease still has a huge space to play.It is expected to open up a new way for the clinical treatment of osteoarthritis by continuing to deepen the research of material preparation and actively carrying out cell and animal experiments.

关 键 词：骨关节炎 软骨修复 软骨组织工程 纳米复合水凝胶 生物材料 生物支架 软骨支架 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R-1