母体用药及母体细胞色素P450遗传多态性与新生儿罹患先天性心脏病的相关性分析  

Correlation of maternal drug use and cytochrome P450 geneticpolymorphisms with congenital heart disease in offspring

作　　者：吴小妹[1] 李慧[1] 王丽 胡春霞[1] WU Xiaomei;LI Hui;WANG Li;HU Chunxia(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Hainan Medical College,Haikou 571000,China)

机构地区：[1]海南医学院第一附属医院妇产科,海南海口571000

出　　处：《西安交通大学学报（医学版）》2023年第4期588-594,共7页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：海南省重点研发计划(No.ZDYF2019162),国家自然基金青年科学基金项目(No.81701459)。

摘　　要：目的研究母亲怀孕早期用药及细胞色素P450(CYP450)遗传多态性与后代先天性心脏病(CHD)的关联性。方法选取127名CHD胎儿产妇为观察组,132名非CHD胎儿产妇为对照组。调查双方特征及用药史,检测CYP450多态性。用Logistic回归分析产妇药物使用与CYP450基因变异与后代CHD风险关联。结果观察组产妇使用促排卵药、降压药、抗生素、抗抑郁药、预防流产药、中药等后代CHD风险高于对照组(P<0.05)。rs1065852基因型中A/T和T/T及rs16947基因型中C/G和G/G相较各自基因型均增加后代CHD风险。母体CYP450基因rs1065852风险基因型(A/T或T/T)及怀孕早期用药可增加后代CHDs风险(P<0.05);CYP450基因rs16947风险基因型(C/G或G/G)同样会增加后代CHDs风险(P<0.05)。结论母体怀孕早期使用药物可能与后代患CHD有关,CYP450的rs1065852和rs16947位点与子代先天性心脏病风险显著相关。Objective To investigate the association of maternal medication during early pregnancy and cytochrome P450(CYP450)genetic polymorphisms with the risk of congenital heart disease(CHD)in offspring.Methods We selected 127 pregnant women with CHD fetuses as the observation group and 132 pregnant women with non-CHD fetuses as the control group.Their characteristics and medication history were investigated,and CYP450 polymorphisms were detected.Logistic regression analysis was used to assess the association between maternal medication,CYP450 gene variations,and offspring CHD risk.Results The risk of CHD in offspring was higher in the observation group with maternal use of ovulation induction drugs,antihypertensive drugs,antibiotics,antidepressants,miscarriage prevention drugs,and traditional Chinese medicine(P<0.05).The A/T and T/T genotypes in rs1065852 and the C/G and G/G genotypes in rs16947 increased the risk of CHD in offspring compared to their respective genotypes.The risk of CHDs in offspring increased with the presence of risk genotypes(A/T or T/T)at the rs1065852 locus of the maternal CYP450 gene and early pregnancy medication use(P<0.05);the same was observed for risk genotypes(C/G or G/G)at the rs16947 locus(P<0.05).Conclusion Maternal medication during early pregnancy may be associated with offspring CHD,and the rs1065852 and rs16947 loci of CYP450 are significantly related to the risk of CHD in offspring.

关 键 词：先天性心脏病 母体用药 细胞色素P450遗传多态性 

分 类 号：R752.4[医药卫生—皮肤病学与性病学] R714[医药卫生—临床医学]