微针介导PDRN纳米脂质体的皮肤渗透性能及抗衰功效研究  

Microneedle-mediated polydeoxyribonucleotide nanoliposomes for skin penetration performance and anti-aging efficacy

作　　者：王曦 洪延寒[1,2] 陈丹 罗丹 张淑婷[3] 马佳月升 张亮韬[4] 刘卫 WANG Xi;HONG Yan-han;CHEN Dan;LUO Dan;ZHANG Shu-ting;MAJIA Yue-sheng;ZHANG Liang-tao;LIU Wei(Wuhan Bestcarrier Biotechnology Co.,Ltd.,Wuhan,Hubei 430075,China;National Engineering Research Center for Nanomedicine,Huazhong University of Science and Technology,Wuhan,Hubei 430075,China;College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China;Youngmay Biotech(Beijing)Ltd.,Beijing 100020,China)

机构地区：[1]武汉百思凯瑞生物科技有限公司,湖北武汉430075 [2]华中科技大学国家纳米药物工程技术研究中心,湖北武汉430075 [3]华中科技大学生命科学与技术学院,湖北武汉430074 [4]样美生物科技(北京)有限公司,北京100020

出　　处：《日用化学品科学》2023年第9期30-34,共5页Detergent & Cosmetics

摘　　要：研究微针介导的多聚脱氧核糖核苷酸(PDRN)经皮输送纳米脂质体(PDRN-NLPS)的皮肤渗透性能及皮肤抗衰功效。PDRN-NLPS的粒径为(50.1±0.2)nm,PDI为0.267±0.008,Zeta电位为(-30.2±0.8)mV。透皮研究表明,微针具有很好的透皮给药效果,纳米脂质体在微针的介导下能够有效促进活性成分快速渗透进入皮肤。细胞抗衰功效研究表明,与游离PDRN溶液比较,PDRN-NLPs显著提高SOD活力、显著增加GSH含量及显著降低MDA水平(P<0.05或P<0.01);能够显著提高ColⅠ、ColⅢ、HA的分泌水平(P<0.05或P<0.01)。The skin penetration properties and skin anti-aging efficacy of microneedle-mediated transdermal delivery of polydeoxyribonucleotide nanoliposomes(PDRN-NLPs)were investigated.The particle size of PDRN-NLPs was(50.1±0.2)nm,the PDI was 0.267±0.008,and the Zeta potential was(-30.2±0.8)mV.The nanoliposomes,mediated by the microneedles,could effectively facilitate the rapid penetration of active ingredients into the skin.Cellular anti-aging efficacy studies showed that PDRN-NLPs significantly increased SOD activity,significantly increased GSH content and significantly decreased MDA level compared with the free component solution(P<0.05 or P<0.01).It significantly increased the secretion levels of Col I,Col III and HA(P<0.05 or P<0.01).

关 键 词：多聚脱氧核糖核苷酸 纳米脂质体 微针 皮肤渗透性能 抗衰功效 

分 类 号：TQ658[化学工程—精细化工]