中医药靶向调控线粒体质量控制系统防治慢性心力衰竭的研究进展  

Research Progress of TCM for the Prevention and Treatment of Chronic Heart Failure by Targeting the Mitochondrial Quality Control System

作　　者：张泸丹 王彬[1] 王新陆[2] 朱明军[2] 赵齐飞 ZHANG Ludan;WANG Bin;WANG Xinlu;ZHU Mingjun;ZHAO Qifei(Henan University of Traditional Chinese Medicine,Zhengzhou 450000 Henan,China;Cardiac Center,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000 Henan,China)

机构地区：[1]河南中医药大学,河南郑州450000 [2]河南中医药大学第一附属医院心脏中心,河南郑州450000

出　　处：《中药新药与临床药理》2023年第7期1017-1024,共8页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金委员会青年科学基金项目(82004343);河南省中医药科学研究专项课题(2019JDZX2027);河南省博士后科研项目(202002076)。

摘　　要：慢性心力衰竭(CHF)患病率高、死亡率高、经济负担重,是重要的公共卫生问题。心肌细胞线粒体作为细胞进行氧化呼吸和能量代谢的主要场所,参与了机体多种病理生理过程,在CHF进程中,其结构和功能的异常是引发心肌能量代谢异常和功能障碍的关键病理环节。线粒体质量控制系统(MQC)是维护线粒体内稳态的基石,包括线粒体氧化应激、生物发生、动力学、自噬和细胞内钙调控等环节。近年来研究发现中医药可靶向调控MQC防治CHF,因此,该文系统地综述中医药靶向调控MQC防治CHF的研究进展,以期为中医药防治CHF提供新的策略和方向。Chronic heart failure(CHF)is a disease with high incidence,high mortality rate,and heavy economic burden,which has become an important public health issue.Mitochondria in myocardial cells are the main site for oxidative respiration and energy metabolism and are involved in various pathological and physiological processes in the body.In the process of CHF,abnormalities of mitochondrial structure and function are key pathological stage leading to abnormalities and dysfunction of myocardial energy metabolism.The mitochondrial quality control system(MQC)is the cornerstone of maintaining mitochondrial homeostasis,including mitochondrial oxidative stress,biogenesis,kinetics,autophagy,and intracellular calcium regulation.In recent years,research has found that traditional Chinese medicine can prevent CHF by targeting the regulation of MQC.For this reason,this article systematically reviews the research progress of traditional Chinese medicine for the prevention and treatment of CHF by targeting the regulation of MQC.Our aim is to provide new strategies and directions of traditional Chinese medicine for the prevention and treatment of CHF.

关 键 词：中医药 靶向调控 慢性心力衰竭 心肌细胞线粒体 线粒体质量控制系统 研究进展 

分 类 号：R285.5[医药卫生—中药学]