腹主动脉瘤与主动脉微循环障碍关系的研究进展  

Research progress in relationship between abdominal aortic aneurysm and aortic microcirculation

作　　者：宋晓红[1] 吴建强 孙晓宁[1] 郑月宏[1] Song Xiaohong;Wu Jianqiang;Sun Xiaoning;Zheng Yuehong(Department of Vascular SurgeryPeking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Medical Research Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院血管外科,北京100730 [2]中国医学科学院北京协和医院医学科学研究中心,北京100730

出　　处：《中华老年多器官疾病杂志》2023年第9期700-703,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然科学基金(51890894,82070492);中国医学科学院医学与健康科技创新工程项目(CIFMS 2021-I2M-1-016);中央高水平医院临床科研专项(2022-PUMCH-C-062)。

摘　　要：腹主动脉瘤(AAA)是一种复杂的受多种因素影响的主动脉疾病。目前,对AAA的研究主要集中在血流紊乱、炎症反应、氧化应激、内皮机械传感器等在AAA发生发展中的作用,其发病机制尚不明确。主动脉微循环是动脉壁血流和血氧的重要来源之一。近年来,越来越多证据表明主动脉微循环障碍可能在AAA发生发展、治疗及预后中发挥重要作用。因此,探究AAA疾病进程中可能的微循环学发病机制,有助于提高和促进对靶向微循环的AAA辅助治疗策略的认识和发展,具有重要的转化医学价值。Abdominal aortic aneurysm(AAA)is a complex aortic disease affected by multiple risk factors.The present studies on AAA mainly focus on the role of blood disorders,inflammation,oxidative stress,and endothelial mechanical sensors in the development of AAA,but the pathogenesis of AAA remains unknown.Aortic microcirculation is one of the important sources of blood perfusion and oxygen in the arterial wall.In recent years,an increasing body of evidence has shown that dysfunction in aortic microcirculation may plays an important role in the development,treatment,and prognosis of AAA.Therefore,exploring the possible microcirculatory pathogenesis in the progression of AAA contributes to the understanding and development of adjuvant therapeutical strategies targeting microcirculation for AAA,implying important value in translational medicine.

关 键 词：腹主动脉瘤 微循环 微血管生成 血管周围脂肪组织 细胞外基质 

分 类 号：R543[医药卫生—心血管疾病]