慢性心力衰竭合并肌少症的诊疗进展  

Progress in diagnosis and treatment of chronic heart failure complicated with sarcopenia

作　　者：王越[1] 张丽晖[1] Wang Yue;Zhang Lihui(Department of Cardiology,Third Hospital of Shanxi Medical University·Shanxi Bethune Hospital·Shanxi Academy of Medical Sciences·Tongji Shanxi Hospital,Taiyuan 030032,China)

机构地区：[1]山西医科大学第三医院·山西白求恩医院·山西医学科学院·同济山西医院心血管内科,太原030032

出　　处：《中华老年多器官疾病杂志》2023年第9期716-720,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：山西省留学回国人员科技活动择优资助项目(2017-1389);山西省应用基础研究项目(201801D121202);山西省回国留学人员科研资助基金(2020-179)。

摘　　要：近年来,慢性心力衰竭(CHF)与肌少症的相关性研究已成为老年医学的热点话题。CHF患者疾病早期即可出现外周骨骼肌组织减少,导致运动能力下降。有研究发现,CHF患者肌少症患病率明显高于健康同龄人。CHF可通过多种病理生理途径引发肌少症,如营养不良、炎症、激素改变、氧化应激以及细胞自噬与细胞凋亡等。同时,肌少症又严重影响着CHF患者的病情进展及预后。此外,由于肌少症的临床表现不明显,患者一旦出现症状,通常意味着肌肉质量和功能的明显衰退,因此,对CHF患者进行肌少症的早期筛查并及时干预显得尤为重要。本文将针对肌少症的筛查及CHF合并肌少症的治疗进展展开综述。In recent years,the research on the correlation between chronic heart failure(CHF)and sarcopenia has become a hot topic in geriatrics.CHF patients can present loss of peripheral skeletal muscle in the early stage of the disease,resulting in a decline in physical activity.Evidence showed that CHF patients have significantly higher prevalence of sarcopenia than healthy age-matched individuals.CHF may cause sarcopenia through a variety of pathophysiological means,such as malnutrition,inflammation,hormone changes,oxidative stress and cell autophagy and apoptosis,etc.At the same time,sarcopenia exerts serious impact on the progression and prognosis of CHF.In addition,since the clinical manifestations of sarcopenia are not obvious,once patients experience symptoms,it usually indicates a significant decline in muscle mass and function.Therefore,it is essential for early screening for sarcopenia in CHF patients and then timely intervention.In this article,we focused on sarcopenia screening and reviewed the diagnosis and treatment of CHF complicated with sarcopenia.

关 键 词：慢性心力衰竭 肌少症 筛查 治疗 

分 类 号：R541[医药卫生—心血管疾病]