卵巢癌侵袭转移机制的生物信息学研究进展  

Progress in bioinformatics research on the invasion and metastasis mechanism of ovarian cancer

作　　者：严玉娟 赵健 宋晓峰[1] YAN Yujuan;ZHAO Jian;SONG Xiaofeng(College of Automation Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing 211106,China)

机构地区：[1]南京航空航天大学自动化学院,南京211106

出　　处：《生物信息学》2023年第3期161-170,共10页Chinese Journal of Bioinformatics

基　　金：国家自然科学基金项目(No.62273175,No.61973155,No.62003165);江苏省重点研发计划项目(No.BE2022843)。

摘　　要：卵巢癌因其侵袭转移特性,致死率极高,居所有妇科恶性肿瘤之首。近年来随着高通量测序技术及生物信息学方法的快速发展,越来越多调控卵巢癌侵袭转移机制的相关生物大分子被发现。本文对卵巢癌侵袭转移机制的研究背景及现状进行了综述,归纳总结了侵袭转移机制相关调控因素,并对蛋白质组学和单细胞组学的生物信息学分析工具及数据库进行了汇总和介绍,以期为卵巢肿瘤细胞侵袭转移机制的深入研究提供理论依据和科研线索。Ovarian cancer is the most lethal of all gynecologic malignancies due to its aggressive and metastatic nature.In recent years,with the rapid development of high-throughput sequencing technology and bioinformatics methods,an increasing number of biomolecules regulating the mechanisms of ovarian cancer invasion and metastasis have been discovered.In this paper,we review the background and current state of research of ovarian cancer invasion and metastasis mechanisms,summarize the regulatory factors for invasion and metastasis mechanisms,collect and describe bioinformatics analysis tools and databases of proteomics and single⁃cellomics,in order to provide theoretical basis and scientific clues for the in⁃depth study of ovarian tumor cell invasion and metastasis mechanisms.

关 键 词：卵巢癌 侵袭转移机制 生物信息学工具 数据库 

分 类 号：Q279[生物学—细胞生物学]