合肥市空气NO_(2)浓度对儿童结膜炎就诊的影响  

Effect of air NO_(2) concentration on conjunctivitis in children in Hefei

作　　者：朱昱 余林玲 肖长春[1] ZHU Yu;YU Lin-ing;XIAO Chang-chun(Hefei Center for Disease Control and Prevention,Hefei,Anhui 230091,China)

机构地区：[1]合肥市疾病预防控制中心,安徽合肥230091

出　　处：《现代预防医学》2023年第17期3118-3122,3132,共6页Modern Preventive Medicine

基　　金：环境健康风险评估试点项目。

摘　　要：目的探讨合肥市空气二氧化氮(nitrogen dioxide,NO_(2))暴露对儿童结膜炎发病就诊的影响。方法收集合肥市2016年11月1日—2019年10月31日某儿童医院儿童结膜炎就诊资料,同时收集同期逐日空气污染物监测资料及气象资料。利用分布滞后非线性模型(distributed lag non-linear model,DLNM),评估NO_(2)浓度对儿童结膜炎就诊量的暴露-滞后-反应关系,模型中调整混杂因素、时间趋势、星期几和节假日等变量。结果研究期间共收集儿童结膜炎就诊26796人次,NO_(2)浓度与儿童结膜炎就诊呈正相关。NO_(2)浓度每上升10μg/m3,结膜炎就诊单日滞后效应在当日(lag0)达到最大,RR为1.055(95%CI:1.038~1.071),累积滞后效应在滞后0~2 d(lag02)达到最大,RR为1.095(95%CI:1.071~1.119)。在男孩、女孩、<6岁和6~14岁结膜炎就诊儿童中,NO_(2)浓度每上升10μg/m3产生的单日滞后效应和累积滞后效应均有统计学意义,单日滞后效应RR(95%CI)分别为1.049(1.028~1.070)、1.066(1.038~1.094)、1.049(1.030~1.067)和1.080(1.041~1.120),累积滞后效应RR(95%CI)分别为1.081(1.052~1.111)、1.123(1.080~1.167)、1.098(1.070~1.126)和1.108(1.055~1.163)。结论合肥市空气NO_(2)浓度升高可能会增加儿童结膜炎就诊风险,且具有滞后效应。Objective To explore the effect of air nitrogen dioxide(NO_(2))exposure on conjunctivitis in children in Hefei.Methods The data of conjunctivitis in a children’s hospital in Hefei from November 1,2016 to October 31,2019 were collected,and the daily air pollutant monitoring data and meteorological data were collected at the same time.The exposure-lag-response relationship of NO_(2) concentration to conjunctivitis in children was evaluated by using the distributed lag nonlinear model(DLNM).The variables such as confounding factors,time trend,day of week,and holiday were adjusted in the model.Results A total of 26796 cases of conjunctivitis in children were collected during the study period.The concentration of NO_(2) was positively correlated with conjunctivitis in children.When the concentration of NO_(2) increased by 10μg/m3,the single-day lag effect of conjunctivitis reached the maximum on the same day(lag0),and the RR was 1.055(95%CI:1.038-1.071).The cumulative lag effect reached the maximum at 0-2 days(lag02),and the RR was 1.095(95%CI:1.071-1.119).In boys,girls,and conjunctivitis children under 6 years old and 6 to 14 years old,the single-day lag effect and cumulative lag effect produced by every 10μg/m3 increase of NO_(2) concentration were statistically significant.The single-day lag effect RR(95%CI)were 1.049(1.028-1.070),1.066(1.038-1.094),1.049(1.030-1.067),and 1.080(1.041-1.120),respectively.The cumulative lag effect RR(95%CI)were 1.081(1.052-1.111),1.123(1.080-1.167),1.098(1.070-1.126),and 1.108(1.055-1.163),respectively.Conclusion The increase of air NO_(2) concentration in Hefei may increase the risk of conjunctivitis in children and has a lag effect.

关 键 词：NO_(2) 结膜炎 分布滞后非线性模型 

分 类 号：R122[医药卫生—环境卫生学] R777.31[医药卫生—公共卫生与预防医学]