两样本孟德尔随机化法探究端粒长度和石棉肺的关联  

Two-sample Mendelian randomization to explore the relationship between telomeree length and asbestosis

作　　者：罗丹 龙丽瑾 兰亚佳 LUO Dan;LONG Li-jin;LAN Ya-jia(West China School of Public Health/West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China;不详)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院,四川成都610041 [2]中国医科大学公共卫生学院

出　　处：《现代预防医学》2023年第17期3123-3127,共5页Modern Preventive Medicine

基　　金：中国医学科学院医学与健康科技创新工程重大协同创新项目(2021-I2M-1-044)

摘　　要：目的采用两样本孟德尔随机化方法探究端粒长度和石棉肺之间可能的因果关系。方法本研究利用与端粒长度相关的遗传变异,采用两样本孟德尔随机化方法评估端粒长度和石棉肺之间可能的因果关系。应用逆方差加权法(IVW)、MR-Egger回归、加权中位数法进行孟德尔随机化分析;采用MR-Egger截距法检验水平多效性;采用留一法进行敏感性分析。结果根据已报道的研究,共提取10个SNPs作为工具变量,逆方差加权法结果显示端粒长度减少可能会增加患石棉肺的风险(OR=0.36,95%CI:0.14~0.90),提示端粒长度每减少一个标准差,石棉肺发生风险增加2.78倍。MR-Egger回归结果表明遗传多效性不会对结果造成偏倚(截距=0.10,P=0.42)。结论本研究结果表明有较短端粒长度遗传倾向的个体患石棉肺的风险可能增加。Objective To explore the possible causal relationship between telomere length and asbestosis by two-sample Mendelian randomization study.Methods Using the genetic variants related to telomere length,two-sample Mendelian randomization method was used to evaluate the possible causal relationship between telomere length and asbestosis.Inverse variance weighting method(IVW),MR-Egger regression,and weighted median method were used for Mendelian randomized analysis.MR-Egger intercept method was used to test horizontal pleiotropy,and leave-one-out method was used for sensitivity analysis.Results According to the published studies,a total of 10 SNPs were extracted as instrumental variables.Results of IVW method showed that the decrease of telomere length might increase the risk of asbestosis(OR=0.36,95%CI:0.14-0.90),suggesting that the risk of asbestosis increased 2.78 times when telomere length decreased by one standard deviation.The results of MR-Egger regression showed that genetic polymorphism did not bias the results(intercept=0.10,P=0.42).Conclusion The results of this study suggest that individuals with a genetic tendency for shorter telomere length may have an increased risk of developing asbestosis.

关 键 词：孟德尔随机化 端粒长度 石棉肺 因果效应 

分 类 号：R181[医药卫生—流行病学]