非稳态负荷评估方法的研究进展  

Research progress of unsteady load evaluation methods

作　　者：贺云铃 王冬雪 廖容[1] 张莉[1] 吴运莲 陶莲德[1] HE Yun-ling;WANG Dong-xue;LIAO Rong;ZHANG Li;WU Yun-lian;TAO Lian-de(Yibin Second People’s Hospital,Sichuan University West China Hospital Yibin Hospital,Yibin,Sichuan 644000,China;不详)

机构地区：[1]宜宾市第二人民医院.四川大学华西医院宜宾医院,四川宜宾644000 [2]哈尔滨医科大学护理学院,黑龙江大庆163319

出　　处：《现代预防医学》2023年第17期3186-3190,共5页Modern Preventive Medicine

摘　　要：非稳态负荷(allostatic load,AL)是反映多个生理系统累积磨损状况的综合指标,能够显著预测个体的身心健康状态。AL的评估包括定量方法和定性方法,其中定量方法使用广泛,但对于非稳态负荷指数(allostatic load index,ALI)计算时生物标志物的选择及计算方法存在相当大的异质性。部分AL研究没有包含神经内分泌系统生物标志物,与其原始概念框架不符。目前ALI计算方法较多,其中最常用的方法为高风险四分位数法,限制了跨样本间研究结果的比较,各种计算方法各具优劣。因此,本文旨在综述AL评估时生物标志物的选择及ALI计算方法及其对研究结果的影响。为未来AL研究中生物标志物的选择及指数计算方法提供参考。Allostatic load(AL)is a comprehensive index reflecting the cumulative wear status of multiple physiological systems,which can significantly predict the physical and mental health of individuals.The evaluation of AL includes quantitative and qualitative methods,with quantitative approaches being more commonly utilized.However,there exists considerable heterogeneity in the selection and calculation methods of biomarkers when determining the allostatic load index(ALI).Some AL studies do not contain biomarkers of neuroendocrine system,which is not consistent with its original conceptual framework.Currently,numerous ALI calculation methods are employed,with the high-risk quartile method being the most prevalent,yet this restricts the comparability of cross-sample research outcomes.Each calculation method has its own advantages and disadvantages.Therefore,the purpose of this paper is to review the selection of biomarkers and ALI calculation methods in the evaluation of AL and its influence on the research results.The purpose of this study is to provide a reference for the selection of biomarkers and index calculation methods in future AL research.

关 键 词：非稳态负荷 非稳态负荷指数 评估 生物标志物 

分 类 号：R181[医药卫生—流行病学]