钯催化的烯烃与三嗪烷氢胺羰基化反应研究  

Palladium-catalyzed Hydroaminocarbonylation of Alkene with Triazine

作　　者：徐鹏程 刘玉玉 钱波[1] 胡斌[1] XU Peng-cheng;LIU Yu-yu;QIAN Bo;HU Bin(State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China;University of Chinese Academy of Sciences,Beijing 100049,China;Northwest Normal University,School of Chemistry and Chemical Engineering,Lanzhou 730070,China)

机构地区：[1]中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室,甘肃兰州730000 [2]中国科学院大学,北京100049 [3]西北师范大学化学化工学院,甘肃兰州730070

出　　处：《分子催化》2023年第3期225-233,I0001,共10页Journal of Molecular Catalysis(China)

基　　金：中国科学院“西部之光”人才培养引进计划。

摘　　要：酰胺类化合物广泛应用于医药、农药、材料、合成化学等领域,因此,新型且高效合成酰胺的方法一直具有很高的关注度.我们首次使用环状脂肪三级胺类化合物—1,3,5-三嗪烷作胺源,成功解决了钯催化的烯烃氢胺羰基化反应领域中脂肪胺对钯催化剂的毒化问题,合成了多种烷基支链酰胺化合物,并提出了可能的反应机理.Amide compounds are widely used in medicine,pesticides,materials,synthetic chemistry and other fields.Therefore,the new and efficient synthesis methods of amides haveattracted high attention of chemists.In this approach,cyclic aliphatic tertiary amine 1,3,5-triazine was first applied as the amine source in the hydroaminocarbonylation transformation of alkene via palladium catalysis,affording virous alkyl branched amide compounds.Additionally,the problem of palladium catalyst poisoning by the aliphatic amine was successfully addressed by this protocol.Furthermore,a possible reaction mechanism is proposed.

关 键 词：钯催化 烯烃 1 3 5-三嗪烷 氢胺羰基化 烷基支链酰胺 

分 类 号：O643[理学—物理化学]