鲁斯可皂苷元在提高力竭运动大鼠运动能力和减轻心肌损伤的作用  

Effects of Ruscogenin in Enhancing Exercise Performance and Alleviating Myocardial Injury in Exhaustive Exercise Rats

作　　者：王焕然 Wang Huanran(Zhengzhou Institute of Science and Technology,Zhengzhou,450064)

机构地区：[1]郑州科技学院,郑州450064

出　　处：《分子植物育种》2023年第18期6199-6206,共8页Molecular Plant Breeding

摘　　要：本研究旨在探讨麦冬活性成分鲁斯可皂苷元对力竭运动大鼠的影响,以及其对运动能力和心肌损伤的调节作用。采用力竭游泳运动模型,通过行为学测试、生化指标检测和组织形态观察,评估了鲁斯可皂苷元对力竭运动大鼠的运动能力、能量代谢、心肌损伤及相关通路的影响。结果显示,鲁斯可皂苷元剂量依赖性地提高了力竭运动大鼠的力竭时间,增加了肝糖原和肌糖原含量,降低了乳酸堆积和血尿素氮水平。此外,鲁斯可皂苷元还减轻了力竭运动大鼠的心肌损伤,改善了心肌组织形态。进一步研究表明,鲁斯可皂苷元通过抑制NLRP3炎症体通路的激活发挥了这些保护作用。综上所述,本研究揭示了麦冬活性成分鲁斯可皂苷元在提高运动能力和减轻心肌损伤方面的潜力,并为其作用机制提供了一定的证据。This studyaimed to investigate the effects of ruscogenin,an active component of Ophiopogon japonicus,on exhaustive exercise rats and its regulatory role in exercise performance and myocardial injury.The exhaustive swimming exercise model was employed,and the effects of ruscogenin on exercise performance,energy metabolism,myocardial injury,and related pathways were evaluated through behavioral tests,biochemical indica-tor measurements,and histological observations.The results showed that ruscogenin dose-dependently increased the exhaustion time in exhaustive exercise rats,increased the levels of hepatic glycogen and muscular glycogen,and decreased lactate accumulation and blood urea nitrogen levels.Moreover,ruscogenin alleviated myocardial in-jury and improved myocardial tissue morphology in exhaustive exercise rats.Further investigations indicated that ruscogenin exerted these protective effects by inhibiting the activation of the NLRP3 inflammasome pathway.In conclusion,this study revealed the potential of ruscogenin,an active component of Ophiopogon japonicus,in en-hancing exercise performance and reducing myocardial injury,providing evidence for its underlying mechanisms.

关 键 词：麦冬 鲁斯可皂苷元 力竭运动 心肌损伤 NLRP3炎症体通路 

分 类 号：R285.5[医药卫生—中药学]