免疫紊乱:与肠道相关的脓毒症病理机制  

Immune Disorders:Pathogenesis of Gut-Associated Sepsis

作　　者：张雨婷 范骏[2] ZHANG Yu-ting;FAN Jun(Graduate School of Medicine,the Second Affiliated Hospital,Nanchang University,Nanchang 330006,China;Department of Emergency,the Second Affiliated Hospital,Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学研究生院医学部,南昌330006 [2]南昌大学第二附属医院急诊科,南昌330006

出　　处：《南昌大学学报（医学版）》2023年第4期85-89,共5页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(81960347)。

摘　　要：免疫紊乱与脓毒症关系密切。在脓毒症发生的过程中免疫亢进与免疫紊乱并存,发病早期以免疫亢进为主。脓毒症患者在机体受到感染时无法完全抑制感染,反复刺激过度激活了炎症反应,从而上调免疫抑制信号分子的表达,并在严重感染时损害机体的免疫器官和免疫细胞使患者免疫功能失调,导致病情出现反复发作。肠道是人体最重要的免疫器官之一,并参与全身免疫调控和淋巴细胞归巢,脓毒症在发生过程中损害肠道屏障功能,最终导致免疫抑制。Immune disorders are closely related to sepsis.In sepsis,immune hyperactivity is the main symptom in the early stage,and coexists with immune disorders.In patients with sepsis,the infection cannot be suppressed completely when the body is infected.Furthermore,repeated stimulation over-activates the inflammatory response to up-regulate the expression of immunosuppressive signal molecules,and damages immune organs and immune cells in severe infection,resulting in immune dysfunction and repeated episodes of sepsis.The gut is one of the most important immune organs in the human body and is involved in systemic immune regulation and lymphocyte homing.Sepsis can impair intestinal barrier function,eventually leading to immunosuppression.

关 键 词：脓毒症 免疫紊乱 肠道屏障 

分 类 号：R459.7[医药卫生—急诊医学]