牛分枝杆菌肉芽肿形成机理的研究进展  

Progress in researches on the formation mechanism of Mycobacterium bovis granuloma

作　　者：于有利 黎玉琼 薛峰[2] YU Youli;LI Yuqiong;XUE Feng(Institute of Animal Science,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan 750002,China;College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]宁夏农林科学院动物科学研究所,宁夏银川750002 [2]南京农业大学动物医学院,江苏南京210095

出　　处：《畜牧与兽医》2023年第8期119-125,共7页Animal Husbandry & Veterinary Medicine

基　　金：宁夏回族自治区农业科技自主创新资金“宁夏牛羊肉产业提质增效关键技术研究与示范”(NGSB-2021-12-06)。

摘　　要：牛结核病(bovine tuberculosis, bTB)是由牛分枝杆菌(Mycobacterium bovis)引起的一种人兽共患的慢性传染病。bTB的发展和转归是宿主的免疫系统和牛分枝杆菌相互斗争的结果,这种斗争最基本和最主要的病理特征之一是形成肉芽肿。因此,阐明肉芽肿的形态特点及参与肉芽肿形成的因素,揭示肉芽肿形成的动态过程,对于了解结核病的发生发展规律,以及研发新的抗结核药物具有重大意义。本文对牛结核肉芽肿的特点、功能以及参与牛结核肉芽肿形成的各种因素进行了综述。Bovine tuberculosis(bTB)is a chronic zoonotic disease caused by Mycobacterium bovis.Following bTB infection,the development and outcome of the infection are the results of a mutual struggle between the host's immune system and Mycobacterium bovis,and one of the most basic and dominant pathological features of this struggle is the formation of granuloma.Therefore,elucidating the morphological characteristics of granuloma and the factors related to its formation is of great significance for revealing the dynamic process of granuloma formation,for studying the development pattern of tuberculosis,and for developing new anti-tuberculosis drugs.This article reviews researches on the characteristics and functions of bovine tuberculosis granuloma and the various factors involved in the formation of this granuloma.

关 键 词：牛结核病 牛分枝杆菌 肉芽肿 

分 类 号：S858.23[农业科学—临床兽医学]