Rapid and efficient characterization of cervical collagen orientation using linearly polarized colposcopic images  

作　　者：Cat Phan Ngoc Khuong Dung Nguyen Huu Quang Hai Pham Thanh Long Nguyen Quynh Nguyen Ngoc Duc Le Huynh Tien Tran Van Tu Ly Anh 

机构地区：[1]Department of Applied Physics Ho Chi Minh City University of Technology 268 Ly Thuong Kiet Street,District 10 Ho Chi Minh City 700000,Vietnam [2]Quality Management Department,Tu Du Hospital 284 Cong Quynh,District 1 Ho Chi Minh City 700000,Vietnam [3]Department of Biomedical Engineering Nguyen Tat Thanh University,300A Nguyen Tat Thanh District 4,Ho Chi Minh City 700000,Vietnam [4]Faculty of Science and Technology Jean Monnet University,11 Rue du Docteur Annino Saint Etienne 42000,France

出　　处：《Journal of Innovative Optical Health Sciences》2023年第5期21-31,共11页创新光学健康科学杂志（英文）

基　　金：supported by the Ho Chi Minh City Department of Science and Technology of Vietnam,under grant number 116/2020/HDQPTKHCN.

摘　　要：Collagen provides tissue strength and structural integrity.Quanti fication of the orientated dispersion of collagen fibers is an important factor when studying the mechanical properties of the cervix.In this study,for the first time,a new method for rapid characterization of the collagen fiber orientations of the cervix using linearly polarized light colposcopy is presented.A total of 24 colposcopic images were captured using a cross-polarized imaging system with white LED light sources.In the preprocessing stage,the Red channel of the RGB image was chosen,which contains no information of the blood vessels because of the low-absorption of blood cells in the red region.OrientationJ,which is an ImageJ plug-in,was used to estimate the local orientation of the collagen fibers.The result shows that in the nonpregnant cervix,the middle zone(Zone 2)has circumferentially aligned collagen fibers while the inner zone(Zone 1)has randomly arranged.The collagen fiber dispersion in Zone 2 is much smaller than that in Zone 1 at all four quadrants region(anterior,posterior,left,and right quadrant).This new analysis technique could potentially combine with diagnostic tools to provide a quantitative platform of collagen fibers in the clinic.

关 键 词：CERVIX collagen fibers collagen orientation COHERENCY cross-polarized imaging COLPOSCOPY 

分 类 号：R318[医药卫生—生物医学工程]