31764例健康体检人群幽门螺杆菌感染影响因素分析  

Analysis of Helicobacter pylori inflfluencing factors in 31764 health physical examination population

作　　者：刘国英[1] 姚浪[1] 邓宁[2,3] 韩玉梅 陈硕[1] LIU Guoying;YAO Lang;DENG Ning;HAN Yumei;CHEN Shuo(Beijing Physical Examination Center,Beijing 100050,China;College of Biomedical Engineering and Instrument Science of Zhejiang University,Hangzhou 310030,Zhejiang,China;Key Laboratory of Biomedical Engineering of Ministry of Education,Beijing 100032,China.)

机构地区：[1]北京市体检中心,北京100050 [2]浙江大学生物医学工程与仪器科学学院,浙江杭州310030 [3]教育部生物医学工程重点实验室,北京100032

出　　处：《健康体检与管理》2023年第3期251-257,共7页Journal of Health Examination and Management

基　　金：国家重点研发计划“主动健康和老龄化科技应对”重点专项项目(2020YFC2003400)。

摘　　要：目的:了解健康体检人群幽门螺杆菌(H.pylori)感染分布及影响因素,为预防H.pylori感染提供健康管理依据。方法:方法:选取2020年5月—2021年11月在北京市体检中心参加健康体检的31764例受检者为研究对象,通过问卷调查收集研究对象一般资料。根据13C-尿素呼气试验结果将研究对象分为H.pylori阴性组和H.pylori阳性组,比较两组在一般资料(性别、年龄、吸烟习惯、饮酒习惯、饮食习惯、睡眠状况、工作体力强度、运动锻炼),体格测量数据[身高、体重、腰围、臀围、体质量指数(BMI)、腰臀围比(W/H)、收缩压、舒张压]以及实验室检验指标[空腹血糖(FPG)、血尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]等方面差异。结果:结果:在31764例研究对象中,其中23507例H.pylori阴性,8257例H.pylori阳性,感染率25.99%(8257/31764)。H.pylori阴性组和阳性组在性别、年龄、吸烟习惯、饮酒习惯、饮食习惯、睡眠状况、工作体力强度、FPG、UA、TC、TG、HDL-C、LDL-C、BMI、W/H、血压水平比较,差异均有统计学意义(P<0.05)。应用Logistic回归模型分析H.pylori感染影响因素,结果显示:男性、30~39岁、吸烟行为、轻度或重度的工作体力强度、好或一般的睡眠状况、全素食,超重、肥胖、FPG升高、LDL-C升高是感染H.pylori的影响因素(P<0.05)。结论:结论:北京地区健康体检人群的H.pylori感染率(25.99%)低于国内部分地区健康体检人群。男性、30~39岁、吸烟行为、轻度或重度的工作体力强度,好或一般的睡眠状况、全素食、超重、肥胖、FPG升高、LDL-C升高是北京地区健康体检人群感染H.pylori的影响因素。Objective:To learn the prevalence and influencing factors of Helicobacter pylori(H.pylori)among people with health examination,to provide management basis for the prevention of H.pylori infection.Methods:Totally 31764 people who participated in health examination at the Beijing Physical Examination Center from May 2020 to November 2021 were selected as research subjects,and the general information of the subjects was collected by questionnaire.Based on the results of ^(13)C urea breath test,the subjects were divided into H.pylori positive group and H.pylori negative group to compare the differences in general information(sex,age,smoking habit,drinking habit,sleep quality,working intensity,exercise),anthropometric data[height,weight,waistline,hipline,body mass index(BMI),waist to hip ratio(W/H),systolic blood pressure and diastolic blood pressure]and laboratory test indexes[fasting blood glucose(FPG),blood uric acid(UA),total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]between two groups.Result:Among the 31764 research subjects,23507 of them are H.pylori negative,8257 of them are H.pylori positive.The infection rate of H.pylori was 25.99%(8257/31764).The differences in gender,age,smoking habit,drinking habit,eating habits,sleeping status,working intensity,FPG,UA,TC,TG,HDL-C,LDL-C,BMI,W/H and blood pressure levels between H.pylori positive group and H.pylori negative group have statistical significance(P<0.05).Logistic regression analysis was used to analyze the influencing factors of H.pylori infection,and the results showed that males,age between 30-39,with smoking habits,mild or high working intensity,good or general sleeping status,vegetarian diet,overweight,obesity,higher FPG,higher LDL-C are important risk factors of H.pylori infection(P<0.05).Conclusion:The infection rate of H.pylori in Beijing was 25.99%which was lower than health physical examination from parts of country.Males,age between 30-39,with smoking habits,mild or high wo

关 键 词：健康体检人群 幽门螺杆菌 影响因素 

分 类 号：R194.3[医药卫生—卫生事业管理]