乳香有效成分治疗冠心病的作用机制研究进展  

Research progress on mechanisms of effective components from Olibanum in treatment of coronary heart disease

作　　者：叶琪 苏宏娜 杨艺 罗培[1,2] 张志锋[1,2] YE Qi;SU Hong-na;YANG Yi;LUO Pei;ZHANG Zhi-feng(College of Traditional Chinese Medicine,Macao University of Science and Technology,Macao 999078,China;Chinese Academy of Sciences State Key Laboratory for Quality Research in Chinese Medicines,Macao university of science and technology,Macao 999078,China)

机构地区：[1]澳门科技大学中医药学院,中国澳门特别行政区999078 [2]中药质量研究国家重点实验室,澳门科技大学,中国澳门特别行政区999078

出　　处：《中草药》2023年第16期5379-5389,共11页Chinese Traditional and Herbal Drugs

基　　金：澳门科学技术发展基金项目(0122/2020/A);澳门科学技术发展基金项目(0043/2021/AGJ)。

摘　　要：乳香Olibanum为活血止痛之常用药,是胸痹心痛方剂中的常用药材。现代研究表明乳香在冠心病的治疗中具有较大的开发前景,其主要活性成分为萜类和挥发油等。通过查阅近年来国内外有关乳香有效成分治疗冠心病的相关文献,综述了乳香单味药材及其有效成分治疗冠心病的作用机制与药效作用的研究进展,列举了含乳香复方的临床应用,并总结了乳香的不良反应,为乳香治疗冠心病的临床应用提供依据与参考。Ruxiang(Olibanum)is a commonly used medicine for promoting blood circulation and relieving pain and is a commonly used medicinal material in prescriptions for chest stuffiness and pains.Modern researches have also confirmed that Olibanum has a great development prospect in treatment of coronary heart disease(CHD),and active ingredients mainly include terpenoids and volatile oils.By reviewing relevant literature on the mechanism of action of the effective components from Olibanum in treatment of CHD both at home and abroad in recent years,this article reviews the research progress on mechanisms and pharmacological effects of Olibanum extract and its effective components in treatment of CHD,lists the clinical applications of prescription containing Olibanum,and summarizes the adverse reactions of Olibanum,providing the basis and references for the clinical application of Olibanum in treating CHD.

关 键 词：乳香 冠心病 作用机制 不良反应 11-羰基-Β-乙酰乳香酸 β-乳香酸 11-羰基-β-乳香酸 

分 类 号：R285[医药卫生—中药学]