仙鹤草化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测分析  

Research progress on chemical constituents and pharmacological action of Agrimoniae Herba and predictive analysis on quality marker

作　　者：张慧兰[1] 郭文晖 王旭[1] 殷启航 万林鹭 唐德才[1] ZHANG Hui-lan;GUO Wen-hui;WANG Xu;YIN Qi-hang;WAN Lin-lu;TANG De-cai(School of Traditional Chinese Medicine,·School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学中医学院·中西医结合学院,江苏南京210023

出　　处：《中草药》2023年第16期5399-5409,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82274116);江苏省中医药科技发展专项(2020ZX01);江苏省研究生科研创新计划项目(KYCX22_1879)。

摘　　要：仙鹤草主要含有黄酮类、酚类、三萜类、糖苷类和鞣质等多种活性成分,其在血液、呼吸、循环、内分泌等系统疾病显示出良好的临床疗效。通过对仙鹤草的化学成分及药理作用进行整合归纳,并结合中药质量标志物(qualitymarker,Q-Marker)新理念,从植物亲缘学、中药药性、有效性证据、化学成分可测性等方面对仙鹤草的Q-Marker进行预测分析。初步预测木犀草素、齐墩果酸、仙鹤草内酯、仙鹤草酚、鹤草酚等成分可作为仙鹤草的主要Q-Marker,为仙鹤草药效物质基础及质量标准提升提供依据。Xianhecao(Agrimoniae Herba)mainly contains a variety of active ingredients such as flavonoids,phenols,triterpenoids,glycosides and tannins,and it shows good clinical effects in hematologic,respiratory,circulatory and endocrine system diseases.By integrating and summarizing the chemical composition and pharmacological effects of Agrimoniae Herba and combining with the new concept of quality marker(Q-Marker)of traditional Chinese medicine,the Q-Marker of Agrimoniae Herba was predicted and analyzed in terms of plant affinities,medicinal properties of traditional Chinese medicines,evidence of effectiveness,and measurability of the chemical compositions.It was initially predicted that lignans,oleanolic acid,agrimonolide,agrimol,and agrimophol could be used as the main Q-Marker of Agrimoniae Herba,which would provide a basis for the material basis of the medicinal effect and the quality standard enhancement of Agrimoniae Herba.

关 键 词：仙鹤草 质量标志物 木犀草素 齐墩果酸 仙鹤草内酯 仙鹤草酚 鹤草酚 

分 类 号：R285[医药卫生—中药学]