香豆素类化学成分的药理作用及毒性机制研究进展  

Research progress on pharmacological action and toxicity mechanism of coumarins

作　　者：董熠 刘丽佳 韩潞雯 廖天琪 许妍妍[1] 李遇伯[1] DONG Yi;LIU Li-jia;HAN Lu-wen;LIAO Tian-qi;XU Yan-yan;LI Yu-bo(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中药学院,天津301617

出　　处：《中草药》2023年第16期5462-5472,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(82004093);国家自然科学基金项目(81873194);国家中医药管理局青年岐黄学者支持项目。

摘　　要：香豆素是一类以苯骈α-吡喃酮为基本结构的芳香族天然产物,根据化学结构可分为简单香豆素、呋喃香豆素、吡喃香豆素和其他香豆素类。该类成分在自然界中分布广泛,现代药理和临床研究表明,中药中香豆素类化合物具有抗肿瘤、抗炎、抗骨质疏松等多种药理活性。然而随着研究的深入与临床的大量应用,中药中香豆素类化合物被发现可致肝脏、肾脏等损伤,其安全性亦引发广泛关注。对中药中香豆素类化学成分及其药理作用进行总结,着重阐述毒性成分(异)补骨脂素、甲氧基补骨脂素、(异)欧前胡素和白花丹醌等的毒性研究进展,以期为中药中香豆素类化合物的研究与合理使用提供科学指导与借鉴,提高含香豆素类成分中药临床用药的有效性与安全性。Coumarins are aromatic substances with benzene and alpha-pyrone as its basic structure,with wide distribution in the natural world.Regarding athe chemical structure of the compound,natural coumarins are mainly classified into four types,simple coumarins,furanocoumarins,pyrancoumarins,and other coumarins respectively.According to numerical modern pharmaceutical literature and clinical studies review,the use of coumarin compounds in traditional Chinese medicine has been reported to exhibit properties of anti-tumor,anti-inflammation,anti-osteoporosis,etc.However,through further deep research and extensive clinical applications using coumarins in traditional Chinese medicine,it is generally found that it is a toxicant,which will cause damage to typical human organs(liver and kidney).Hence,the safety of using coumarins had become a major concern to the whole society.This paper summarized the chemical components and the pharmacological actions that coumarins compounds obtained in Chinese herbal medicine,particularly emphasized the research progress on toxicity levels for poisonous components[(iso)psoralen,methoxy psoralen,(iso)imperatorin,plumbagin,etc].It also aims to provide scientific guidance and references for future research and rational use and promote both the effectiveness and safety of coumarins in clinical practice.

关 键 词：香豆素 补骨脂素 甲氧基补骨脂素 欧前胡素 白花丹醌 抗肿瘤 抗炎 抗骨质疏松 毒性机制 

分 类 号：R28[医药卫生—中药学]