温脾补肾方煎服辅助治疗对早中期慢性肾衰竭患者中医证候积分及氧化应激反应的影响研究  

Study on the Effect of Decoction Adjuvant Therapy with Recipe for Warming the Spleen and Tonifying the Kidney on the TCM Evidence Score and Oxidative Stress Response in Patients with Early to Mid-stage Chronic Renal Failure

作　　者：王旭 Wang Xu(Changge Hospital of Traditional Chinese Medicine,Xuchang,Henan,461500,China)

机构地区：[1]长葛市中医院,河南许昌461500

出　　处：《黑龙江医学》2023年第17期2109-2112,共4页Heilongjiang Medical Journal

摘　　要：目的:探究温脾补肾方煎服辅助治疗对早中期慢性肾衰竭(CRF)脾肾阳虚型患者中医证候积分及氧化应激反应的影响。方法:选取2019年1月—2021年10月长葛市中医院收治的84例早中期CRF脾肾阳虚型患者作为研究对象,按随机数表法分为A组和B组,每组各42例。B组接受常规西药治疗,A组在B组的基础上联合温脾补肾方煎服辅助治疗。对比两组患者总有效率、治疗前后肾功能指标[尿素氮(BUN)、血清肌酐(SCr)、24 h尿蛋白定量(24 h Upro)]、中医证候积分、炎性因子指标[白细胞介素-18 (IL-18)、细胞间黏附分子-1 (ICAM-1)、白细胞介素-6 (IL-6)]、氧化应激指标[活性氧(ROS)、超氧化物歧化酶(SOD)、总抗氧化能力(TAC)]水平。结果:A组总有效率高于B组,差异有统计学意义(χ^(2)=6.574,P<0.05)。治疗3个月后,A组食少纳呆、气短懒言、畏寒肢冷、腰酸膝软中医证候积分均低于B组,差异有统计学意义(t=13.986、4.830、6.378、10.835,P<0.05)。治疗3个月后,A组BUN、SCr、24 h Upro水平均低于B组,差异有统计学意义(t=6.798、6.879、29.345,P<0.05)。治疗3个月后,A组血清IL-18、IL-6、ICAM-1水平均低于B组,差异有统计学意义(t=13.397、6.517、14.675,P<0.05)。治疗3个月后,A组血清ROS水平低于B组,血清SOD、TAC水平均高于B组,差异有统计学意义(t=7.954、13.772、6.334,P<0.05)。结论:温脾补肾方煎服辅助治疗早中期CRF脾肾阳虚型患者效果显著,可有效促进患者肾功能改善,减轻其机体氧化应激反应、微炎症状态,促进其临床症状改善。Objective:To investigate the effect of decoction adjuvant therapy with recipe for warming the spleen and tonifying the kidney on the TCM evidence score and oxidative stress response in patients with early to mid-stage chronic renal failure(CRF)spleen-kidney yang deficiency type.Methods:84 patients with early to mid-stage CRF spleen-kidney-yang deficiency type admitted to the hospital from January 2019 to October 2021 were selected for the study and divided into group A and group B according to the random number table method,with 42 cases in each group.Group B received conventional western medicine treatment,and Group A was combined with the decoction of Warming the Spleen and Tonifying the Kidney formula as an adjunctive treatment on the basis of Group B.The total efficiency,renal function indexes(urea nitrogen [BUN],serum creatinine [SCr],24 h urine protein quantification [24 h Upro]),Chinese medicine evidence score,inflammatory factor indexes(interleukin-18 [IL-18],intercellular adhesion molecule-1 [ICAM-1],interleukin-6 [IL-6]),oxidative stress indexes(reactive oxygen species [ROS],superoxide dismutase[SOD],total antioxidant capacity [TAC]) levels were compared between the two groups.Results:The total effective rate in group A was higher than that in group B,and the difference was statistically significant(χ^(2)=6.574,P<0.05).After 3 months of treatment,the TCM symptom scores of less food and dullness,shortness of breath and lazy speech,coldness in the extremities and lumbago in group A were lower than those in group B,and the differences were statistically significant(t=13.986,4.830,6.378,10.835,P<0.05).After 3 months of treatment,the levels of BUN,SCr,and 24 h Upro in group A were lower than those in group B,and the differences were statistically significant(t=6.798,6.879,29.345,P<0.05).After 3 months of treatment,serum IL-18,IL-6 and ICAM-1 levels in group A were lower than those in group B,and the differences were statistically significant(t=13.397,6.517,14.675,P<0.05).After 3 months of treatment,the seru

关 键 词：慢性肾衰竭 氧化应激 微炎症状态 温脾补肾方 

分 类 号：R692.5[医药卫生—泌尿科学]