Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance  

作　　者：Chang-Soo Han Ji-Hyun Kang Eun hye Park Hyo-Jung Lee So-Jeong Jeong Dong-Wook Kim Chun-Woong Park 

机构地区：[1]College of Pharmacy,Chungbuk National University,Cheongju 28160,Republic of Korea [2]School of Pharmacy,Jeonbuk National University,Jeonju 54896,Republic of Korea [3]College of Pharmacy,Wonkwang University,Iksan 54538,Republic of Korea

出　　处：《Asian Journal of Pharmaceutical Sciences》2023年第3期146-158,共13页亚洲药物制剂科学（英文）

基　　金：supported by a National Research Foundation of Korea grant provided by the Korean government(NRF-2021R1A2C4002746 and 2017R1A5A2015541);This research was supported by"Regional Innovation Strategy(RIS)"through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(MOE)(2021RIS-001);Finally,this work was supported by a funding for the academic research program of Chungbuk National University in 2022.

摘　　要：Corrugated surface microparticles comprising levofloxacin(LEV),chitosan and organic acid were prepared using the 3-combo spray drying method.The amount and the boiling point of the organic acid affected the degree of roughness.In this study,we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder inhaler.HMP175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid solution.The ACI and PIV results showed a significant increase in aerodynamic performance of corrugated microparticles.The FPF value of HMP175 L20 was 41.3%±3.9%compared with 25.6%±7.7%of HMF175 L20.Corrugated microparticles also showed better aerosolization,decreased x-axial velocity,and variable angle.Rapid dissolution of drug formulationswas observed in vivo.Lowdoses administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered orally.Surface modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.

关 键 词：CHITOSAN Organic acid LEVOFLOXACIN Corrugated surface Aerodynamic performance 

分 类 号：R96[医药卫生—药理学]