代谢综合征合并HBV感染患者糖脂代谢、内皮功能及颈动脉狭窄程度研究  

Glucose and Lipid Metabolism,Endothelial Function and Carotid Stenosis in Patients with Metabolic Syndrome Complicated with HBV Infection

作　　者：孙传俊 文正燕 SUN Chuanjun;WEN Zhengyan(Clinical Laboratory,Xinxiang Infectious Disease Hospital,Xinxiang 453000,China;Department of Gastroenterology,Xinxiang Infectious Disease Hospital,Xinxiang 453000,China)

机构地区：[1]新乡市传染病医院检验科,河南新乡453000 [2]新乡市传染病医院消化内科,河南新乡453000

出　　处：《河南医学研究》2023年第18期3322-3324,共3页Henan Medical Research

摘　　要：目的 探讨代谢综合征(MS)合并乙型肝炎病毒(HBV)感染患者糖脂代谢、内皮功能及颈动脉狭窄程度。方法 选取2020年3月至2021年3月新乡市传染病医院收治的96例MS患者作为研究对象,根据是否合并HBV感染分为感染组(35例)和未感染组(61例)。比较两组糖代谢指标[空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)]、脂代谢指标[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平]、内皮功能[心电图R波出现肱动脉内径(D1)、反应性充血后最大的肱动脉内径(D2)]、颈动脉内膜中层厚度(IMT)。结果 感染组患者FPG、HbA1c、FINS、TC、TG、LDL-C水平和IMT高于未感染组,HDL-C水平低于未感染组(P<0.05);两组D1、D2肱动脉内径基础值差异无统计学意义(P>0.05)。结论 MS合并HBV感染患者糖代谢和脂代谢水平升高,颈动脉狭窄程度增加,内皮功能受损。Objective To investigate the glucose and lipid metabolism,endothelial function and carotid artery stenosis in patients with metabolic syndrome(MS)complicated with hepatitis B virus(HBV)infection.Methods A total of 96 patients with MS admitted to the Xinxiang Infectious Disease Hospital from March 2020 to March 2021 were selected as the research objects,and were divided into infected group(35 cases)and uninfected group(61 cases)according to whether they were infected with HBV.The glucose metabolism indexes[fasting insulin(FINS),glycosylated hemoglobin(HbA1c),fasting blood glucose(FBG)],lipid metabolism indexes[triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],endothelial function indexes[brachial artery diameter with electrocardiogram R wave(D1),maximum brachial artery diameter after reactive congestion(D2)]and carotid intima-media thickness(IMT)were compared between the two groups.Results The levels of FPG,HbA1c,FINS,TC,TG,LDL-C and IMT in the infected group were higher than those in the uninfected group,and the level of HDL-C was lower than that in the uninfected group(P<0.05).There was no statistical difference in the basic value of brachial artery diameter between the two groups(P>0.05).Conclusion Patients with MS complicated with HBV infection have increased glucose metabolism and lipid metabolism,increased carotid stenosis and impaired endothelial function.

关 键 词：乙型肝炎病毒 代谢综合征 内皮功能 颈动脉狭窄 

分 类 号：R589[医药卫生—内分泌]