肝脾CT测量值、MMP因子在抗结核药物致肝损伤中临床意义  

Clinical Significance of Liver and Spleen CT Measurement Value and MMP Factor in Liver Injury Caused by Anti-tuberculosis Drugs

作　　者：郭洋洋 闫慧敏 刘冠立 曹卫云 徐高杰 王雪艳 GUO Yangyang;YAN Huimin;LIU Guanli(Department of Radiology,Kaifeng 155 Hospital,Kaifeng City,He’nan Province 475003)

机构地区：[1]开封一五五医院放射科,河南省开封市475003

出　　处：《医学理论与实践》2023年第18期3077-3080,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨肝脾CT测量值联合基质金属蛋白酶(MMP)因子水平评估抗结核药物致肝损伤的临床意义。方法:选取2020年1月—2022年5月在我院治疗的抗结核药物致肝损伤患者88例作为观察组,选取同期未发生抗结核药物致肝损伤患者120例作为对照组,比较两组肝脾CT测量值、MMP-1、MMP-2、MMP-7、MMP-9、MMP-13和MMP-14差异;同时分析观察组不同肝损伤分级患者肝脾CT测量值等差异。结果:观察组肝CT测量值、脾CT测量值、肝/脾CT测量比值、肝与脾CT测量差值、MMP因子水平与对照组比较差异显著(P<0.05)。不同程度肝损伤患者肝CT测量值、肝与脾CT测量差值、肝/脾CT测量比值对比差异显著(P<0.05)。重度肝损伤患者MMP-1、MMP-9和MMP-14明显高于轻度和中度肝损伤患者(P<0.05)。中度肝损伤患MMP-1和MMP-9明显高于轻度肝损伤患者(P<0.05)。肝CT测量值、肝/脾CT测量比值、肝与脾CT测量差值、MMP-1、MMP-9与肝损伤分级具有相关性(P<0.05)。肝CT测量值与MMP-9呈负相关(P<0.05)。结论:抗结核药物致肝损伤患者肝脾CT测量值降低,血清MMP因子水平升高,同时CT测量值、MMP-1和MMP-9与患者肝损伤分级存在相关性,值得进一步研究。Objective:To investigate the clinical significance of liver and spleen CT measurement combined with matrix metalloproteinase(MMP)in evaluating liver injury induced by anti-tuberculosis drugs.Methods:From January 2020 to May 2022,88 patients with liver injury caused by anti-tuberculosis drugs treated in our hospital were selected as the observation group,and 120 patients without liver injury caused by anti-tuberculosis drugs in the same period were selected as the control group,the differences of liver and spleen CT measurements,MMP-1,MMP-2,MMP-7,MMP-9,MMP-13 and MMP-14 between the two groups were compared.At the same time,the differences of CT measurement of liver and spleen and so on in patients with different liver injury grades in the observation group were analyzed.Results:There were significant differences between the observation group and the control group in liver CT measurement value,spleen CT measurement value,liver/spleen CT measurement ratio,liver and spleen CT measurement difference,MMP factor level(P<0.05).There were significant differences in liver CT measurement value,liver and spleen CT measurement difference and liver/spleen CT measurement ratio among the patients with different degrees of liver injury(P<0.05).MMP-1,MMP-9 and MMP-14 in patients with severe liver injury were significantly higher than those in patients with mild and moderate liver injury(P<0.05).MMP-1 and MMP-9 in patients with moderate liver injury were significantly higher than those in patients with mild liver injury(P<0.05).The liver CT measurement value,liver/spleen CT measurement ratio,liver/spleen CT measurement difference,MMP-1,MMP-9 were correlated with the liver injury grade(P<0.05).There was a negative correlation between liver CT measurement and MMP-9(P<0.05).Conclusion:In patients with liver injury caused by anti-tuberculosis drugs,the CT measurement value of liver and spleen decrease,and the level of serum MMP factor increase,and the CT measurement value,MMP-1 and MMP-9 are correlated with the liver injury grade of pa

关 键 词：肝脾CT测量值 基质金属蛋白酶 抗结核药物致肝损伤 肝损伤分级 

分 类 号：R595.3[医药卫生—内科学]