血清CKMT1A、NFL检测联合^(11)C-β-CFT PET/CT脑显像在帕金森病诊断中的价值  

The value of serum CKMT1A and NFL detection combined with ^(11)C-β-CFT PET/CT brain imaging in the diagnosis of Parkinson's disease

作　　者：常培叶[1] 薛婧婷 王春梅[1] 赵平 CHANG Pei-Ye;XUE Jing-Ting;WANG Chun-Mei(Department of Nuclear Medicine,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China)

机构地区：[1]内蒙古医科大学附属医院核医学科,内蒙古呼和浩特010050 [2]内蒙古自治区人民医院心内科

出　　处：《中国老年学杂志》2023年第18期4424-4427,共4页Chinese Journal of Gerontology

基　　金：国家自然科学基金地区项目(81760319);内蒙古自然科学基金面上项目(2020MS08035);内蒙古科技计划项目(2022YFSH0039)。

摘　　要：目的探究帕金森病(PD)患者血清线粒体肌酸激酶(CKMT)1A、神经丝轻链蛋白(NFL)活性的变化及^(11)C-甲基-N-2β-甲基酯-3β-(4-F-苯基)托烷(^(11)C-β-CFT)正电子发射计算机断层显像(PET)/电子计算机X射线断层扫描技术(CT)脑显像的情况,为发现PD标志物提供线索。方法PD患者39例为PD组,对照组50例来自健康体检者,使用酶联免疫吸附试验测定血清CKMT1A、NFL浓度,使用^(11)C-β-CFT PET/CT显示黑质、纹状体多巴胺转运体(DAT)的摄取情况。结果PD组血清CKMT1A、NFL水平明显高于对照组(P<0.05);PD组纹状体DAT结合量指数及结合不对称性显著低于对照组(P<0.05)。结论CKMT1A、NFL联合^(11)C-β-CFT PET/CT脑显像有可能成为辅助诊断PD的标志物。Objective To investigate the changes of serum mitochondrial creatine kinase(CKMT)1A and neurofilament light chain protein(NFL)activity in patients with Parkinson's disease(PD)and the changes of ^(11)C-β-CFT position emission computed tomography(PET)/computed tomography(CT)brain imaging,which could provide clues for the discovery of PD markers.Methods There were 39 PD patients in PD group and control group with 50 healthy physical examination subjects.Serum CKMT1A and NFL levels were measured by enzyme-linked immunosorbent assay,^(11)C-β-CFT PET/CT showed uptake of substantia nigra and striatal dopamine transporter(DAT).Results The levels of serum CKMT1A and NFL in PD group were significantly higher than those in the control group(P<0.05);the DAT binding index and the DAT binding asymmetry in the striatum in PD group were significantly lower than those in the control group(P<0.05).Conclusions CKMT1A,NFL combined with ^(11)C-β-CFT PET/CT brain imaging might be a marker for auxiliary diagnosis of PD.

关 键 词：帕金森病 多巴胺转运体 线粒体肌酸激酶1A 神经丝轻链蛋白 

分 类 号：R446.62[医药卫生—诊断学]