TLR3 rs3775290与慢性乙型肝炎病毒感染风险的相关性研究  

Association of TLR3 rs3775290 and chronic hepatitis B virus infection

作　　者：董文杰[1] 阎小霞 贾彦彬 解英波[2] 高芳[1] DONG Wenjie;YAN Xiaoxia;JIA Yanbin;XIE Yingbo;GaoFang(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,China;Center for Disease Control and Prevention of Baotou)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]包头市疾病预防控制中心

出　　处：《包头医学院学报》2023年第9期8-11,39,共5页Journal of Baotou Medical College

基　　金：包头医学院科学研究基金项目(自然科学类青苗计划BYJJ-QM-2018009)。

摘　　要：目的:探讨TLR3基因SNP rs3775290与慢性乙型肝炎病毒感染性风险的关系。方法:应用病例对照研究方法,在内蒙古鄂尔多斯市选取172例慢性乙型肝炎患者(作为CHB病例组)和200例健康者(作为对照组)。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)法检测CHB病例组和对照组TLR3基因SNP rs3775290位点的基因多态性。并用非条件性Logisic回归计算比值比(OR)及其95%可信区间(CI)以评估等位基因、基因型与慢性乙肝发病风险的关系。结果:SNP rs3775290位点在对照组中GG、AG、AG基因型的频率分别为50.5%、39.5%、10.0%,CHB病例组GG、AG、AA基因型的频率分别为56.4%、34.9%、8.7%,两组差异无统计学意义(P>0.05)。rs3775290位点在共显性遗传模型、显性遗传模型、隐性遗传模型、超显性遗传模型下均与慢性HBV感染风险无关(P>0.05)。结论:TLR3 rs3775290与内蒙古鄂尔多斯市汉族人群慢性乙型肝炎病毒感染无风险关联。Objective:To investigate the relationship between Toll-Like Receptor 3(TLR3)rs3775290 and the risk of chronic hepatitis B virus infection.Methods:A total of 172 patients with chronic hepatitis B were selected as the CHB case group and 200 healthy people as the control group in Ordos,Inner Mongolia.Polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP)was used to detect the gene polymorphism of TLR3 rs3775290 in the CHB case group and the control group.The odds ratio(OR)and its 95%confidence interval(CI)were calculated by non-conditional Logistic regression to assess the relationship between alleles,genotypes and the risk of chronic hepatitis B infection.Results:Frequencies of SNP rs3775290 on GG,AG and AG genotypes in the control group were 50.5%,39.5%and 10.0%respectively,while the frequencies in the CHB case group were 56.4%,34.9%and 8.7%respectively.There was no significant difference between the two groups(P>0.05).SNP rs3775290 was not associated with the risk of chronic HBV infection under codominant genetic model,dominant genetic model,recessive genetic model and super dominant genetic model(P>0.05).Conclusion:TLR3 rs3775290 has no relationship with the risk of chronic hepatitis B virus infection in Han population in Ordos,Inner Mongolia.

关 键 词：TLR3 基因多态性 慢性乙型肝炎 rs 3775290 

分 类 号：R512.62[医药卫生—内科学]