ZFhx3基因变异与心房颤动、脑梗死和肺血栓栓塞的关系  

Correlation of the transcription factor zinc finger homeobox 3 gene variation with atrial fibrillation,cerebral infarction,and lung thromboembolism

作　　者：柏松 黄博雅 李津 张竹芬 张毅茹 曹玉萍[1] 张国彦[1] BAI Song;HUANG Boya;LI Jin(Baoding No.1 Central Hospital,Hebei,Baoding 071000,China)

机构地区：[1]河北省保定市第一中心医院,071000

出　　处：《河北医药》2023年第18期2794-2797,共4页Hebei Medical Journal

基　　金：保定市科学技术研究与发展计划项目(编号:2141ZF085)。

摘　　要：目的 通过现象学扫描研究老年人群中单核苷酸多态性(SNP) rs2106261,在转录因子ZFhx3基因、心房颤动(AF)及其他相关表型中的表达。方法 本研究从老年疾病SNP数据库(JG-SNP)中检索连续的临床体检数据(n=2 433,平均年龄80岁)。收集医疗图表临床资料,包括AF诊断。采用DNA芯片法进行基因分型。还分析42个病理和26个临床表型,包括脑梗死(CI)和肺血栓栓塞(LT),在临床体检中通过肉眼检查诊断。结果 2 433例患者中,18.6%为心房颤动(AF),29.4%为CI,4.9%为LT表现型。经年龄、性别、糖尿病、高血压和吸烟校正后,rs2106261 SNP的A等位基因与AF显著相关(AA+AG/GG,OR=1.51,95%CI:1.16~1.97,P=0.002)。CI与rs2106261无关(P=0.14)。然而,在<80岁的患者中,rs2106261与CI显著相关(AA+AG/GG,OR=1.57,95%CI:1.09~2.26,P=0.01)。LT也与rs2106261相关(AA+AG/GG,OR=1.99,95%CI:1.31~3.01,P=0.001)。在对AF的存在进行调整后,rs2106261与CI和LT的相关性仍为阳性,表明该SNP变异可能作为一个独立的风险标记。结论 ZFHX3基因多态性rs2106261 (A等位基因)是AF及AF相关表型的风险标记。Objective To investigate the expression of single nucleotide polymorphism(SNP)rs2106261 in the transcription factor zinc finger homeobox 3 gene(ZFHX3),atrial fibrillation(AF)and other relevant phenotypes in the elderly by phenomenological scanning.Methods In the present study,consecutive physical examination data(n=2433,mean age of 80 years)were retrieved from the Japanese SNP database for Geriatric Research(JG-SNP).Clinical data on medical charts,including AF diagnoses were collected.Genotyping was performed by DNA microassay.A total of 42 pathological and 26 clinical phenotypes were also analyzed,including cerebral infarction(CI)and lung thromboembolism(LT),which were diagnosed by visual inspection during physical examination.Results Of the 2433 patients,18.6%,29.4%and 4.9%of them had the phenotype of AF,CI and LT,respectively.After adjustment for age,gender,diabetes,hypertension and smoking,the A allele of rs2106261 SNP was significantly correlated with AF(AA+AG/GG,OR=1.51,95%confidence interval[CI]:1.16-1.97,P=0.002).CI was not correlated with rs2106261(P=0.14).However,rs2106261 was significantly correlated with CI in patients with the age of 80 years and below(AA+AG/GG,OR=1.57,95%CI:1.09-2.26,P=0.01).LT was also significantly correlated with rs2106261(AA+AG/GG,OR=1.99,95%CI:1.31-3.01,P=0.001).After adjusting for the presence of AF,rs2106261 was still positively correlated with CI and LT,suggesting that the SNP mutation may be an independent risk marker.Conclusion ZFHX3 polymorphism rs2106261(A allele)is a risk marker for AF and AF-related phenotypes.

关 键 词：ZFhx3基因 心房颤动 脑梗死 肺血栓栓塞 

分 类 号：R657.44[医药卫生—外科学]