213例中医药辅助治疗晚期结直肠癌病例回顾性分析  

Retrospective Analysis on TCM Adjunctive Therapy for 213 Cases of Advanced Colorectal Cancer

作　　者：张葛[1] 胡佳奇 秦晓艳 李道睿[1] 刘浩[1] 李丛煌[1] 花宝金[1] ZHANG Ge;HU Jiaqi;QIN Xiaoyan;LI Daorui;LIU Hao;LI Conghuang;HUA Baojin(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中医药信息杂志》2023年第9期155-161,共7页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：中国中医科学院科技创新工程项目(CI2021B009);新疆生产建设兵团科技局资助项目(2022CD018)。

摘　　要：目的观察晚期结直肠癌中医干预后的流行病学趋势与相关指标。方法回顾性分析2000年1月1日-2011年12月31日中国中医科学院广安门医院肿瘤科中医药辅助治疗的213例晚期结直肠癌患者,通过对既往治疗的总结与随访,观察中医药辅助治疗对晚期结直肠癌的疗效与作用,并在既往研究基础上对影响中晚期结直肠癌预后的相关因素进行COX回归分析,筛选出有利因素及不利因素,探索结直肠癌中医病机的发展规律。结果COX回归分析显示,肝转移为预后不良因素,有肝转移的患者死亡风险为无肝转移患者的1.473倍(HR=1.473)。中西医结合组进展风险低于中医组,进展风险为中医组的40.7%。结论本研究收治的晚期结直肠癌病例基本符合当时国际流行病学变化趋势,脾肾阳虚为最为常见的辨证类型,经COX回归分析,肝转移是总生存期不利的预后因素,中西医结合治疗可降低疾病进展风险。Objective To observe the epidemiological trends and related indicators of advanced colorectal cancer after TCM intervention.Methods This study retrospectively analyzed 213 patients with advanced colorectal cancer who received TCM adjuvant treatment in the Department of Oncology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences from 1,Jan.2000 to 31,Dec.2011.Through the summary and follow-up of previous treatment,the therapeutic effect and role of TCM in the treatment of advanced colorectal cancer were observed.On the basis of previous research,COX regression analysis was used to analyze the relevant factors affecting the prognosis of advanced colorectal cancer,and screen out the favorable and unfavorable factors,to explore the development laws of TCM pathogenesis of colorectal cancer.Results The COX regression analysis showed that liver metastasis was a poor prognostic factor,and the risk of death in patients with liver metastasis was 1.473 times higher than in patients without liver metastasis(HR=1.473).The progression risk of the integrated traditional Chinese and Western medicine group was lower than that of the TCM group,with a progression risk of 40.7%compared to the TCM group.Conclusion The cases of advanced colorectal cancer included in the study are basically in line with the international epidemiological trends at that time.Spleen and kidney yang deficiency is the most common type of syndrome.COX regression analysis shows that liver metastasis is an unfavorable prognostic factor for overall survival,and the integration of traditional Chinese and Western medicine treatment can reduce the risk of disease progression.

关 键 词：结直肠癌 中医治疗 中西医结合治疗 肝转移 脾肾阳虚 回顾性分析 预后不良因素 

分 类 号：R273.53[医药卫生—中西医结合]