中药提取物调控脊髓损伤后血-脊髓屏障机制研究进展  

Research Progress in the Mechanism of Chinese Herbal Extracts Regulating Blood-Spinal Cord Barrier after Spinal Cord Injury

作　　者：赵志恒[1] 赵曼霖 王越[1] 徐家淳 周震[1] 李岩[3] ZHAO Zhiheng;ZHAO Manlin;WANG Yue;XU Jiachun;ZHOU Zhen;LI Yan(Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Public Security Hospital,Tianjin 300042,China)

机构地区：[1]天津中医药大学第二附属医院,天津300250 [2]天津中医药大学,天津301617 [3]天津市公安医院,天津300042

出　　处：《中国中医药信息杂志》2023年第9期192-196,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82174191);天津市教委科研计划项目(2022KJ181、2019KJ049)。

摘　　要：脊髓损伤后继发性神经损伤的病理生理过程主要与血-脊髓屏障破坏有关。脊髓损伤属中医学“痿证”“体惰”范畴,疏通督脉是中医治疗脊髓损伤主要原则,以活血、消肿、清热、益气等方法为主,具有此类功效的中药提取物对神经功能恢复具有积极作用。本文归纳近年脊髓损伤后血-脊髓屏障损伤机制研究,发现中药提取物对脊髓损伤后血-脊髓屏障损伤的修复策略主要与脊髓水肿、炎症反应、细胞凋亡与自噬等作用密切相关,为中医药治疗脊髓损伤机制研究及临床应用提供思路。The pathophysiological process of secondary nerve injury after spinal cord injury is mainly related to the rupture of blood-spinal cord barrier(BSCB).Spinal cord injury belongs to the category of“Weizheng”and“Tiduo”in TCM.Dredging the Governor Vessel is the main strategy of treating spinal cord injury in TCM.Chinese herbal extracts with the main methods of promoting blood circulation,reducing swelling,clearing heat,and tonifying qi have a positive effect on the recovery of neurological function.In this article,by reviewing the injury mechanism of BSCB after spinal cord injury in recent years,it was found that the repair strategies of Chinese herbal extracts on BSCB injuries after spinal cord injury were closely related to spinal cord edema,inflammation,apoptosis and autophagy,etc.,in order to provide ideas for the machanism research and clinical application of TCM in the treatment of spinal cord injury.

关 键 词：中药提取物 脊髓损伤 血-脊髓屏障 神经血管单元 脊髓水肿 炎症反应 细胞凋亡 综述 

分 类 号：R285[医药卫生—中药学]