生物成像用二氧杂环丁烷余辉发光体系的研究进展  

Recent advances of dioxetane-based afterglow system for bio-imaging

作　　者：吕程远 张函[1] 杨明旺[1] 杜健军[1] 樊江莉[1,2] LYU Chengyuan;ZHANG Han;YANG Mingwang;DU Jianjun;FAN Jiangli(Frontiers Science Center for Smart Materials Oriented Chemical Engineering,State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,Liaoning,China;Ningbo Institute of Dalian University of Technology,Ningbo 315016,Zhejiang,China)

机构地区：[1]大连理工大学智能材料化工前沿科学中心,精细化工国家重点实验室,辽宁大连116024 [2]大连理工大学宁波研究院,浙江宁波315016

出　　处：《化工进展》2023年第8期4108-4122,共15页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金(21925802);中央高校基础研究基金(DUT22LAB601);NSFC-辽宁联合基金(U1908202)。

摘　　要：余辉发光成像方式规避了样本中自体荧光的干扰,极大地降低了背景信号,显著提高了成像信噪比。近年来,基于光氧化反应的二氧杂环丁烷余辉发光体系受到研究者的关注。此类余辉发光体系具有良好的生物相容性与水氧耐受性,易于制备并进行结构修饰,能够实现多功能成像的要求,在疾病诊疗过程中有着广泛的应用前景。本文简述了二氧杂环丁烷余辉发光体系所涉及到的发光机理,并在此基础上总结了体系的构建方式。之后列举出近年来二氧杂环丁烷余辉发光体系应用在肿瘤示踪与手术导航、生物活性分子成像和医学诊疗等方面中的突破性工作。最后,对目前的研究进展进行总结概括,并分析了该体系在临床应用上面临的挑战和对未来的发展进行了展望。Afterglow imaging avoids the interference of autofluorescence,dramatically reduces the background signal,and significantly improves the imaging signal-to-noise ratio.Recently,the dioxetane afterglow system that bases on photo-oxidation reaction has attracted wide attention.This afterglow system has good biocompatibility,improved aqueous and oxygen tolerance capability,and is easily synthesized and modified.Moreover,this form of afterglow can realize the requirements of multifunctional imaging and has a broad application prospect in the disease diagnosis and treatment process.In this review,the luminescence mechanism of the dioxetane-based afterglow system is briefly described,and the construction method of the system is summarized.The recent breakthroughs in surgical navigation,bioactive molecular imaging,diagnosis,and treatment are also listed.Finally,this review summarizes the current research progress of the dioxetane-based afterglow system,analyses the challenges confronted with the clinical application and prospects the development of this system in future.

关 键 词：光化学 生物成像 化学反应 氧化 二氧杂环丁烷体系 余辉发光 诊疗 

分 类 号：TQ619.7[化学工程—精细化工]