A群轮状病毒感染性腹泻患儿体液免疫功能与脱水性酸中毒的相关性  

Correlation between Humoral Immune Function and Dehydration Acidosis in Children with Rotavirus Group A Infectious Diarrhea

作　　者：王慧 王平平 WANG Hui;WANG Ping-ping(Department of Pediatrics,No.924 Hospital of the Joint Command and Security Forces of the People's Liberation Army,Guilin Guangxi 541001,China;Department of Pharmacy,No.924 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army,Guilin Guangxi 541001,China)

机构地区：[1]中国人民解放军联勤保障部队第九二四医院儿科,广西桂林541001 [2]中国人民解放军联勤保障部队第九二四医院药剂科,广西桂林541001

出　　处：《中华养生保健》2023年第19期11-14,共4页CHINESE HEALTH CARE

摘　　要：目的探讨与分析A群轮状病毒感染性腹泻患儿体液免疫功能与脱水性酸中毒的相关性。方法选择2021年7月-2022年12月中国人民解放军联勤保障部队第九二四医院收治的80例A群轮状病毒感染性腹泻患儿为轮状病毒组,同期选择在中国人民解放军联勤保障部队第九二四医院收治的80例非轮状病毒感染性腹泻患儿作为对照组。所有患儿在入院后判定发生脱水性酸中毒,检测患儿的体液免疫功能并进行相关性分析。结果轮状病毒组的脱水性酸中毒发生率为13.75%,对照组为2.50%,轮状病毒组明显高于对照组(P<0.05)。轮状病毒组的血清IgA、IgM、IgG含量与对照组相比均明显降低(P<0.05)。在轮状病毒组,Spearsman分析显示脱水性酸中毒的发生与血清IgA、IgM、IgG含量均存在负相关性(P<0.05)。多元二分类Logistic回归分析显示,血清IgA、IgM、IgG含量降低为导致A群轮状病毒感染性腹泻患儿发生脱水性酸中毒的重要危险因素(P<0.05)。结论A群轮状病毒感染性腹泻患儿多伴随脱水性酸中毒,体液免疫功能也会下降,A群轮状病毒感染性腹泻患儿体液免疫功能与脱水性酸中毒存在相关性。Objective ToMethods explore and analysis the correlation between humoral immune function and dehydration acidosis in children with rotavirus group A infectious diarrhea.Methods From July 2021 to December 2022,80 cases of children with group A rotavirus infectious diarrhea diagnosed and treated in the 924 Hospital of the Joint Service Support Force of the People's Liberation Army of China were selected as the rotavirus group,and the other 80 cases of children with non-rotavirus infectious diarrhea diagnosed and treated in our hospital were selected as the control group.After admission,all children were judged the occurrence of dehydrated acidosis,and their humoral immune function were tested and correlation analysis were performed.Results The incidence rates of dehydration acidosis in rotavirus group were 13.75%,and that in control group were 2.50%,the incidence rates of dehydration acidosis in rotavirus group were signifi cantly higher than that in control group(P<0.05).The contents of serum IgA,IgM and IgG in rotavirus group were signifi cantly lower than those in control group(P<0.05).In the rotavirus group,Spearman analysis showed that there were negative correlation between dehydrated acidosis and serum IgA,IgM and IgG levels(P<0.05).Multiple dichotomy logistic regression analysis showed that the contents of serum IgA,IgM and IgG were important risk factors for dehydration acidosis in children with rotavirus group A infectious diarrhea(P<0.05).Conclusion Children with group A rotavirus infectious diarrhea are often accompanied by dehydration acidosis,and humoral immune function will also decline.There is a correlation between humoral immune function and dehydration acidosis in children with group A rotavirus infectious diarrhea.

关 键 词：A群轮状病毒 感染性腹泻 脱水性酸中毒 体液免疫功能 相关性 多因素分析 

分 类 号：R725.1[医药卫生—儿科]