猪繁殖与呼吸综合征病毒结构蛋白和非结构蛋白研究进展  

Progress on Structural and Nonstructural Proteins of Porcine Reproductive and Eespiratory Syndrome Virus

作　　者：陈旭 汤德元[1] 曾智勇[1] 王彬[1] 陈阊峥 罗柳 袁盛林 廖正波 CHEN Xu;TANG De-yuan;ZENG Zhi-yong;WANG Bin;CHEN Chang-zheng;LUO Liu;YUAN Sheng-lin;LIAO Zheng-bo(College of Animal Science,Guizhou University,Guiyang,Guizhou,550025,China)

机构地区：[1]贵州大学动物科学学院,贵州贵阳550025

出　　处：《动物医学进展》2023年第9期76-81,共6页Progress In Veterinary Medicine

基　　金：贵州省科技支撑计划项目(黔科合支撑[2021]一般162)。

摘　　要：猪繁殖与呼吸综合征病毒(PRRSV)主要引起以母猪流产、产死胎、弱胎、木乃伊胎以及仔猪呼吸困难、败血症为特征的猪繁殖与呼吸综合征(PRRS),该病传播快、传染性强,是规模化养猪场常见的接触性传染病之一。PRRSV基因组编码GP2a、E、GP3、GP4、GP5、GP5a、M、N等8种结构蛋白和NSP1α、NSP1β、NSP2-NSP8、NSP9-NSP12等至少13种非结构蛋白。论文从三个角度对PRRSV结构蛋白和非结构蛋白进行综述,包括PRRSV感染宿主后结构蛋白和非结构蛋白发挥的作用、它们对宿主信号通路的影响和基于两类蛋白的检测方法,以期为进一步研究PRRSV的致病机制以及防治猪繁殖与呼吸综合征病毒病奠定理论基础。Porcine reproductive and respiratory syndrome virus(PRRSV)mainly causes porcine reproductive and respiratory syndrome(PRRS),which is characterized by miscarriage of sows,stillbirth,weak birth,mummified birth,and dyspnea and septicemia of piglets.PRRS spreads quickly and is highly infectious,which is one of the common infectious diseases in large-scale pig farms.The PRRSV genome encodes 8 structural proteins(GP2a,E,GP3,GP4,GP5,GP5a,M,N)and at least 13 non-structural proteins(NSP1α,NSP1β,NSP2-NSP8,NSP9-NSP12).This paper reviews the structural and non-structural proteins of PRRSV from three perspectives,including the role of structural and non-structural proteins after PRRSV infection of the host,their influence on the host signaling pathway,and detection methods based on the two classes of proteins,in order to lay a theoretical foundation for further research on the pathogenesis of PRRSV and prevention and treatment of porcine reproductive and respiratory syndrome virus disease.

关 键 词：猪繁殖和呼吸综合征病毒 结构蛋白 非结构蛋白 信号通路 诊断 

分 类 号：S852.659.6[农业科学—基础兽医学]