2020年广州市健康人群麻疹、风疹和流行性腮腺炎抗体水平调查  

Antibody levels against measles,rubella,and mumps among healthy people in Guangzhou:a cross-sectional survey in 2020

作　　者：贺晴[1] 许杨[1] 李意兰[1] 罗雷[1] 朱娉婷 He Qing;Xu Yang;Li Yilan;Luo Lei;Zhu Pingting(Guangzhou Center for Disease Control and Prevention/Institute of Public Health of Guangzhou Medical University,Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,Guangdong,China)

机构地区：[1]广州市疾病预防控制中心/广州市疾病预防控制中心广州医科大学公共卫生研究院,广东广州510440

出　　处：《中国疫苗和免疫》2023年第4期392-396,共5页Chinese Journal of Vaccines and Immunization

基　　金：广州市卫生健康委一般引导项目(20221A011073);广州市医学重点学科(2021-2023-11)。

摘　　要：目的 了解广州市健康人群麻疹、风疹和流行性腮腺炎(流腮)抗体水平。方法 采用横断面调查方法抽取广州市健康人群,检测血清麻疹、风疹和流腮IgG抗体,分析抗体阳性率和几何平均浓度(Geometric mean concentration, GMC)。结果 在1 099名调查对象中,麻疹、风疹、流腮IgG抗体总阳性率分别为89.99%、80.16%、84.99%,GMC分别为1 052.29mIU/mL、58.48IU/mL、511.53U/mL。0-7月龄、8-17月龄、18-35月龄、3-5岁、6-11岁、12-17岁、≥18岁人群麻疹抗体阳性率分别为57.45%、85.71%、98.62%、95.95%、91.27%、85.71%、92.63%,风疹抗体阳性率分别为48.94%、80.95%、91.72%、88.26%、79.64%、60.71%、77.89%,流腮抗体阳性率分别为55.32%、64.76%、83.45%、94.33%、93.09%、85.71%、88.95%。结论 2020年广州市健康人群麻疹、风疹和流腮抗体总体低于或介于群体免疫阈值;应重点关注0-7月龄和12-17岁儿童的疫情发生风险。Objective To explore antibody levels against measles,rubella,and mumps in Guangzhou healthy people.Methods We conducted a cross-sectional survey of healthy people in Guangzhou and tested sera for IgG antibodies against measles,rubella,and mumps to determine positivity rates and geometric mean concentrations(GMCs).Results Among the 1099 subjects,positivity rates of measles,rubella,and mumps antibodies were 89.99%,80.16%,and 84.99%,with GMCs being 1052.29mIU/mL,58.48IU/mL,and 511.53U/mL,respectively.For 0-7-month-olds,8-17-month-olds,18-35-month-olds,3-5-year-olds,6-11-year-olds,12-17-year-olds,and≥18-year-olds,positivity rates of measles antibody were 57.45%,85.71%,98.62%,95.95%,91.27%,85.71%,and 92.63%;positivity rates of rubella antibody were 48.94%,80.95%,91.72%,88.26%,79.64%,60.71%,and 77.89%;positivity rates of mumps antibody were 55.32%,64.76%,83.45%,94.33%,93.09%,85.71%,and 88.95%.Conclusions The antibody levels of measles,rubella,and mumps in Guangzhou were below or in the thresholds of herd immunity.We should focus on the risk of disease and outbreaks in 0-7-month-old and 12-17-year-old children.

关 键 词：麻疹 风疹 流行性腮腺炎 IGG抗体 

分 类 号：R186[医药卫生—流行病学]