吉林省2017-2021年2-75岁健康人群百日咳毒素抗体水平调查  

A cross-sectional survey of pertussis toxin antibody levels in a 2-75 year-old healthy population in Jilin province from 2017 to 2021

作　　者：付思美[1] 王锦 李春梅[1] 程涛[1] 田鑫[1] 曹凤瑞[1] 李永强 孙朦 季尚玮[3] 王爽[1] Fu Simei;Wang Jin;Li Chunmei;Cheng Tao;Tian Xin;Cao Fengrui;Li Yongqiang;Sun Meng;Ji Shangwei;Wang Shuang(Jilin Provincial Center for Disease Control and Prevention,Changchun 130062,Jilin,China;School of Public Health,Jilin University,Changchun 130062,Jilin,China;Norman Bethune Third Hospital of Jilin University,Changchun 130062,Jilin,China)

机构地区：[1]吉林省疾病预防控制中心,吉林长春130062 [2]吉林大学公共卫生学院,吉林长春130062 [3]吉林大学白求恩第三医院,吉林长春130062

出　　处：《中国疫苗和免疫》2023年第4期402-406,共5页Chinese Journal of Vaccines and Immunization

摘　　要：目的 了解吉林省健康人群百日咳毒素IgG(PT-IgG)水平,分析百日咳急性感染率和易感率。方法 采用方便抽样法抽取2017-2021年吉林省2-75岁健康人群,采用酶联免疫吸附试验检测血清PT-IgG,分析PT-IgG中位数浓度(Median concentration, MC)、浓度≥100IU/mL(急性感染)和<5IU/mL(易感)比例。结果 在3 893名调查对象中,PT-IgG MC、≥100IU/mL比例、<5IU/mL比例分别为7.27IU/mL、2.83%、38.99%。2-4岁、5-6岁、7-14岁、15-19岁、20-29岁、30-39岁、40-49岁、50-75岁人群PT-IgG≥100IU/mL比例分别为2.18%、4.02%、3.15%、4.07%、3.02%、1.94%、3.28%、1.73%(χ2=9.31,P=0.232),<5IU/mL比例分别为46.97%、44.18%、44.37%、39.84%、41.43%、35.06%、33.49%、30.58%(χ2=46.18,P<0.001)。2-14岁儿童含百日咳成分疫苗全程接种后12-23月、2-4年、5-9年、≥10年PT-IgG≥100IU/mL比例分别为4.29%、3.74%、5.32%、9.09%(χ2=2.00,P=0.573)。结论 2017-2021年吉林省2-75岁健康人群存在百日咳急性感染且易感率较高;建议优化儿童含百日咳成分免疫程序,研发适用于青少年和成人的含百日咳成分疫苗。Objective To explore pertussis toxin IgG(PT-IgG)levels in healthy people of Jilin province and determine presence of acute infection and susceptibility to pertussis.Methods We selected healthy individuals 2-75 years of age during 2017 to 2021 in Jilin using a convenience sampling method.We obtained and tested sera for PT-IgG by enzyme-linked immunosorbent assay and calculated PT-IgG median concentration(MC)and proportions with PT-IgG≥100 IU/mL(consistent with acute infection)and<5IU/mL(consistent with susceptibility).Results Among 3893 subjects,the PT-IgG MC and proportions with PT-IgG≥100IU/mL and<5IU/mL were 7.27IU/mL,2.83%,and 38.99%,respectively.Proportions of PT-IgG≥100IU/mL for 2-4-,5-6-,7-14-,15-19-,20-29-,30-39-,40-49-,and 50-75-year-olds were 2.18%,4.02%,3.15%,4.07%,3.02%,1.94%,3.28%,and 1.73%(χ2=9.31,P=0.232),with proportions of<5IU/mL being 46.97%,44.18%,44.37%,39.84%,41.43%,35.06%,33.49%,and 30.58%(χ^(2)=46.18,P<0.001).Among children 2-14 years of age who had received full-series pertussis vaccination,at 12-23 months,2-4 years,5-9 years,and≥10 years of age,proportions with PT-IgG≥100IU/mL were 4.29%,3.74%,5.32%,and 9.09%(χ^(2)=2.00,P=0.573).Conclusions Healthy people 2-75 years of age in Jilin from 2017 to 2021 showed both evidence of acute infection and high susceptibility to pertussis.We recommend optimizing the childhood pertussis immunization schedule and developing pertussis-containing vaccines for adolescents and adults.

关 键 词：百日咳 百日咳毒素IgG抗体 急性感染 易感性 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]