中药熏洗促进痔疮术后创面愈合用药规律研究  

Study on medication rule of TCM fumigation and washing in promoting the postoperative healing of hemorrhoids

作　　者：姜芸 李莹倩 李宇飞[3] 曾译贤 袁润 雷沥 李华山[3] Jiang Yun;Li Yingqian;Li Yufei;Zeng Yixian;Yuan Run;Lei Li;Li Huashan(Beijing University of Chinese Medicine,Beijing 100029,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Anorectal,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院广安门医院,北京100053 [3]中国中医科学院广安门医院肛肠科,北京100053

出　　处：《国际中医中药杂志》2023年第8期1034-1038,共5页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82174390)。

摘　　要：目的运用数据挖掘技术分析中药熏洗促进痔疮术后创面愈合用药规律。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)和PubMed建库至2022年3月10日收录的中药熏洗促进痔疮术后创面愈合的文献。采用古今医案云平台(V2.3.5)对中药频次、属性、功效、核心药对、核心处方等进行分析。结果共纳入处方299首,涉及中药200味,使用频次≥40次的高频用药有苦参、黄柏、芒硝、五倍子、大黄等,功效以清热燥湿为主,药性以寒、温、微寒居多,药味以苦、辛、甘、酸居多,以归肝、胃、心、大肠、脾、肺经为主;关联分析得到22条规则,聚类分析得到5组药物,复杂网络分析得到核心处方组成为苦参、黄柏、芒硝、五倍子、大黄、蒲公英、冰片、地榆、苍术、红花、黄芩、乳香、没药、金银花。结论中药熏洗促进痔疮术后创面愈合以清热燥湿解毒为主,兼以活血化瘀、消肿止痛、敛疮生肌。Objective To analyze the medication law of Traditional Chinese Medicine(TCM)fumigation and washing to promote postoperative healing of hemorrhoids by data mining technology.Methods The clinical literature about TCM fumigation and washing to promote postoperative healing of hemorrhoids was retrieved from the databases of CNKI,Wanfang,VIP,PubMed from the establishment of the databases to March 10,2022.The frequency efficacy attributes,core medicinal pairs and core prescriptions of TCM were analyzed by using the Ancient and Modern Medical Records Cloud Platform(V2.3.5).Results A total of 299 articles were included,involving 200 kinds of Chinese materia medica.The drugs used at high frequency≥40 were Sophorae Flavescentis Radix,Phellodendri Chinensis Cortex,Natrii Sulfas,Galla Chinensis and Rhei Radix et Rhizoma and so on.The main efficacy was to clear heat and reduce dampness;cold,warm and slightly cold were the main medicinal properties,and the tastes were mainly bitter,pungent,sweet and sour,and most of the drugs return to the liver meridian,stomach meridian,heart meridian,large intestine meridian and so on.A total of 22 rules were obtained by correlation analysis.Five groups of drugs were obtained by clustering analysis.The core prescription drugs obtained by complex network analysis included Sophorae Flavescentis Radix,Phellodendri Chinensis Cortex,Natrii Sulfas,Galla Chinensis,Rhei Radix et Rhizoma,Taraxaci Herba,Borneolum Syntheticum,Sanguisorbae Radix,Atractylodis Rhizoma,Carthami Flos,Scutellariae Radix,Olibanum,Myrrha,and Lonicerae Japonicae Flos.Conclusion TCM fumigation and washing can promote the postoperative healing of hemorrhoids mainly by clearing heat and reducing dampness and detoxification,as well as promoting blood circulation and removing blood stasis,reducing swelling and relieving pain,restraining sore and generating muscle.

关 键 词：痔 中药熏洗法 创面愈合 数据挖掘 用药规律 古今医案云平台 

分 类 号：R266[医药卫生—中医外科学]